Clodronate

Known as: CLOD 
A nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate. Clodronate disodium binds to calcium and inhibits osteoclastic bone… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
BACKGROUND Adding oral clodronate to postoperative adjuvant breast cancer therapy significantly improves disease-free survival… (More)
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Highly Cited
2004
Highly Cited
2004
Lymphangiogenesis, an important initial step in tumor metastasis and transplant sensitization, is mediated by the action of VEGF… (More)
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Highly Cited
2004
Highly Cited
2004
Ten-year follow-up results are presented of an adjuvant clodronate trial in patients with primary breast cancer. Between 1990 and… (More)
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Highly Cited
2002
Highly Cited
2002
Bisphosphonates are currently the most important class of antiresorptive drugs used for the treatment of diseases with excess… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE The development of bone metastases depends on tumor-induced osteoclastic resorption of bone, which may be inhibited by… (More)
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Highly Cited
2001
Highly Cited
2001
PURPOSE Bisphosphonates have effectively reduced the development and progression of bone metastases in advanced breast cancer… (More)
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Highly Cited
2000
Highly Cited
2000
OBJECTIVE To assess whether intraarticular (IA) administration of clodronate liposomes results in local macrophage depletion in… (More)
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Highly Cited
1996
Highly Cited
1996
Liposomes can be used as vehicles for intracellular delivery of drugs into phagocytic cells. Clodronate and propamidine… (More)
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Highly Cited
1996
Highly Cited
1996
Bisphosphonates (BPs), such as clodronate and pamidronate, are inhibitors of bone resorption and are used on a widespread basis… (More)
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Highly Cited
1993
Highly Cited
1993
PURPOSE Osteolytic metastases often give rise to hypercalcemia, fracture, and bone pain, and occur commonly in patients with… (More)
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