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Clodronate

Known as: CLOD 
A nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate. Clodronate disodium binds to calcium and inhibits osteoclastic bone… Expand
National Institutes of Health

Papers overview

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Review
2017
Review
2017
BACKGROUND Bisphosphonates are specific inhibitors of osteoclastic activity and are used in the treatment of patients with… Expand
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Highly Cited
2002
Highly Cited
2002
Bisphosphonates are currently the most important class of antiresorptive drugs used for the treatment of diseases with excess… Expand
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Highly Cited
2002
Highly Cited
2002
PURPOSE The development of bone metastases depends on tumor-induced osteoclastic resorption of bone, which may be inhibited by… Expand
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Highly Cited
2000
Highly Cited
2000
OBJECTIVE To assess whether intraarticular (IA) administration of clodronate liposomes results in local macrophage depletion in… Expand
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Highly Cited
1998
Highly Cited
1998
Bisphosphonates are currently the most important class of antiresorptive drugs used for the treatment of metabolic bone diseases… Expand
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Highly Cited
1998
Highly Cited
1998
In patients with multiple myeloma, despite a major reduction of bone pain achieved with chemotherapy, skeletal disease continues… Expand
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Highly Cited
1996
Highly Cited
1996
Liposomes can be used as vehicles for intracellular delivery of drugs into phagocytic cells. Clodronate and propamidine… Expand
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Highly Cited
1995
Highly Cited
1995
Bisphosphonates inhibit bone resorption and are therapeutically effective in diseases of increased bone turnover, such as Paget's… Expand
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Highly Cited
1993
Highly Cited
1993
PURPOSE Osteolytic metastases often give rise to hypercalcemia, fracture, and bone pain, and occur commonly in patients with… Expand
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Highly Cited
1992
Highly Cited
1992
Osteolytic lesions and pathological fractures are common in multiple myeloma. Because clodronate inhibits osteoclastic resorption… Expand
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