Central Nervous System Sensitization

Known as: Sensitization, Central, Central Sensitization, Sensitizations, Central 
An increased response to stimulation that is mediated by amplification of signaling in the CENTRAL NERVOUS SYSTEM (CNS).
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and synaptic efficacy of neurons in central… (More)
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
2011
Highly Cited
2011
Central sensitization provides an evidence-based explanation for many cases of 'unexplained' chronic musculoskeletal pain. Prior… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Review
2010
Review
2010
Central sensitization plays an important role in the pathophysiology of numerous musculoskeletal pain disorders, yet it remains… (More)
  • figure 1
  • table 1
  • table 2
  • figure 2
  • table 3
Is this relevant?
Highly Cited
2009
Highly Cited
2009
c-Fos, the protein of the protooncogene c-fos, has been extensively used as a marker for the activation of nociceptive neurons in… (More)
  • table 1
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Molecular mechanisms underlying C-fiber stimulation-induced ERK (extracellular signal-regulated kinase) activation in dorsal horn… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?
Highly Cited
2004
Highly Cited
2004
We have shown that the development of cutaneous allodynia (exaggerated skin sensitivity) during migraine is detrimental to the… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
In previous studies, we have shown that loss of spinal neurons that possess the substance P receptor (SPR) attenuated pain and… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
Review
1999
Review
1999
Nerve signals arising from sites of tissue or nerve injury lead to long-term changes in the central nervous system and contribute… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Brain-derived neurotrophic factor (BDNF) is expressed in nociceptive sensory neurons and transported anterogradely to the dorsal… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1997
Highly Cited
1997
BACKGROUND & AIMS Only a fraction of patients with irritable bowel syndrome (IBS) show hypersensitivity to rectal distention. The… (More)
Is this relevant?