Central Nervous System Sensitization

Known as: Sensitization, Central, Central Sensitization, Sensitizations, Central 
An increased response to stimulation that is mediated by amplification of signaling in the CENTRAL NERVOUS SYSTEM (CNS).
National Institutes of Health

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Review
2011
Review
2011
Central sensitization: Implications for the diagnosis and treatment of pain
Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and synaptic efficacy of neurons in central… (More)
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Highly Cited
2011
Highly Cited
2011
How to explain central sensitization to patients with 'unexplained' chronic musculoskeletal pain: practice guidelines.
Central sensitization provides an evidence-based explanation for many cases of 'unexplained' chronic musculoskeletal pain. Prior… (More)
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Review
2010
Review
2010
Recognition of central sensitization in patients with musculoskeletal pain: Application of pain neurophysiology in manual therapy practice.
Central sensitization plays an important role in the pathophysiology of numerous musculoskeletal pain disorders, yet it remains… (More)
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Highly Cited
2009
Highly Cited
2009
c-Fos and pERK, which is a better marker for neuronal activation and central sensitization after noxious stimulation and tissue injury?
c-Fos, the protein of the protooncogene c-fos, has been extensively used as a marker for the activation of nociceptive neurons in… (More)
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Highly Cited
2004
Highly Cited
2004
Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal…
Molecular mechanisms underlying C-fiber stimulation-induced ERK (extracellular signal-regulated kinase) activation in dorsal horn… (More)
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Highly Cited
2004
Highly Cited
2004
Analgesic triptan action in an animal model of intracranial pain: a race against the development of central sensitization.
We have shown that the development of cutaneous allodynia (exaggerated skin sensitivity) during migraine is detrimental to the… (More)
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Highly Cited
2002
Highly Cited
2002
Spinal neurons that possess the substance P receptor are required for the development of central sensitization.
In previous studies, we have shown that loss of spinal neurons that possess the substance P receptor (SPR) attenuated pain and… (More)
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Review
1999
Review
1999
Central nervous system plasticity and persistent pain.
Nerve signals arising from sites of tissue or nerve injury lead to long-term changes in the central nervous system and contribute… (More)
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Highly Cited
1999
Highly Cited
1999
Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity.
Brain-derived neurotrophic factor (BDNF) is expressed in nociceptive sensory neurons and transported anterogradely to the dorsal… (More)
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Highly Cited
1997
Highly Cited
1997
Repetitive sigmoid stimulation induces rectal hyperalgesia in patients with irritable bowel syndrome.
BACKGROUND & AIMS Only a fraction of patients with irritable bowel syndrome (IBS) show hypersensitivity to rectal distention. The… (More)
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