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Carboplatin/Etoposide/Melphalan Regimen

Known as: CEM, CEM Regimen 
A regimen containing carboplatin, etoposide and melphalan used for the treatment of childhood neuroblastoma.
National Institutes of Health

Related topics

Related topics

4 relations
Chronic Lymphocytic LeukemiaCyclophosphamidePrednisoneVincristine

Papers overview

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Highly Cited
2001
Highly Cited
2001
Apaf-1 protein deficiency confers resistance to cytochrome c-dependent apoptosis in human leukemic cells.
The human leukemia cell lines K562, CEM, CEM/VLB(100), human leukemic blasts, and the bladder cancer J82 cell line have different… 
Highly Cited
2001
Highly Cited
2001
Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells.
Thioguanine and mercaptopurine are prodrugs requiring conversion into thiopurine nucleotides to exert cytotoxicity. Thiopurine S… 
Highly Cited
2001
Highly Cited
2001
Synthesis, characterisation, X-ray structure and biological activity of three new 5-formyluracil thiosemicarbazone complexes.
Review
2000
Review
2000
Characterization of MLH1 and MSH2 DNA mismatch repair proteins in cell lines of the NCI anticancer drug screen
Purpose and methods: The lack of a functional DNA mismatch repair (MMR) pathway has been recognized as a common characteristic of… 
Highly Cited
1999
Highly Cited
1999
Subcellular distribution and redistribution of Bcl-2 family proteins in human leukemia cells undergoing apoptosis.
It has been suggested that the ratio of Bcl-2 family proapoptotic proteins to antiapoptotic proteins determines the sensitivity… 
Highly Cited
1998
Highly Cited
1998
Cadmium induces apoptosis differentially on immune system cell lines.
Highly Cited
1994
Highly Cited
1994
Role of vif during packing of the core of HIV-1.
The viral infectivity factor gene vif of human immunodeficiency virus type 1 (HIV-1) has been shown to enhance the cell-free… 
Highly Cited
1991
Highly Cited
1991
Alteration of HIV-1 infectivity and neutralization by a single amino acid replacement in the V3 loop domain.
The V3 loop (residues 303-338) of the human immunodeficiency virus type 1 (HIV-1) gp120 envelope protein represents a principal… 
Highly Cited
1983
Highly Cited
1983
Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
Methotrexate (MTX)-resistant sublines of malignant human cells were selected in vitro by stepwise increase in drug concentration… 
Highly Cited
1979
Highly Cited
1979
Biochemical determinants of tumor sensitivity to 5-fluorouracil: ultrasensitive methods for the determination of 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthetase.
Techniques have been developed to measure FdUMP, the active metabolite of 5-FUra; thymidylate synthetase (TMP synthase; 5,10… 
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