Vincristine

Known as: VCR, Vincristin, 22-Oxovincaleukoblastine 
A natural alkaloid isolated from the plant Vinca rosea Linn. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1955-2018
020040060080019552017

Related topics

Related topics

48 relations

Broader (1)

Antineoplastic Agents, Phytogenic
CAFVP protocolCEV regimenCMFVP protocolCOPAD protocol
(More)

Narrower (14)

CCV protocolCE-AVN protocolCEOP-B protocolCHOP protocol-cyclophosphamide/doxorubicin/prednisone/vincristine
(More)

Related mentions per year

Related mentions per year

1937-2018
1960198020002020
Vincristine
VAD I protocol
CHOP protocol-cyclophosphamide/doxorubicin/prednisone/vincristine
VAC Regimen (Vincristine-Dactinomycin-Cyclophosphamide)
MOPP protocol
cyclophosphamide/prednisone/vincristine protocol

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group study 26951.
PURPOSE Anaplastic oligodendroglioma are chemotherapy-sensitive tumors. We now present the long-term follow-up findings of a… (More)
Is this relevant?
Highly Cited
2009
Highly Cited
2009
NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide.
PURPOSE The standard of care for anaplastic gliomas is surgery followed by radiotherapy. The NOA-04 phase III trial compared… (More)
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Phase III study of R-CVP compared with cyclophosphamide, vincristine, and prednisone alone in patients with previously untreated advanced follicular lymphoma.
PURPOSE To compare the long-term outcome of patients with previously untreated follicular lymphoma (FL) needing therapy, after… (More)
  • table 1
  • figure 1
  • figure 2
  • table 2
  • figure 3
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized…
PURPOSE Anaplastic oligodendrogliomas are more responsive to chemotherapy than high-grade astrocytomas. We investigated, in a… (More)
  • figure 1
  • table 2
  • table 1
  • table 3
  • table 4
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Frontline therapy with rituximab added to the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) significantly improves the outcome for patients with advanced-stage…
Phase 2 studies suggest that the monoclonal antibody rituximab may improve the prognosis of patients with follicular lymphoma (FL… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy.
Paclitaxel (Taxol) is one of the most effective and frequently used chemotherapeutics for the treatment of solid tumours. However… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma.
BACKGROUND The standard treatment for patients with diffuse large-B-cell lymphoma is cyclophosphamide, doxorubicin, vincristine… (More)
  • figure 1
  • figure 2
  • table 4
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning
Diffuse large B-cell lymphoma (DLBCL), the most common lymphoid malignancy in adults, is curable in less than 50% of patients… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1982
Highly Cited
1982
Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.
Some calcium antagonists and calmodulin inhibitors enhance the intracellular levels of vincristine and Adriamycin in vincristine… (More)
  • table 2
  • table 1
  • table 3
Is this relevant?
Highly Cited
1981
Highly Cited
1981
Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.
A noncytotoxic dose of verapamil, a coronary vasodilator, enhances the cytotoxicity of vincristine (VCR) and vinblastine in P388… (More)
  • table 1
  • table 2
Is this relevant?