Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Carbonyl Reductase [NADPH] 3

Known as: Carbonyl Reductase 3, NADPH-Dependent Carbonyl Reductase 3, EC 1.1.1.184 
Carbonyl reductase [NADPH] 3 (277 aa, ~31 kDa) is encoded by the human CBR3 gene. This protein plays a role in the reduction of metabolically active… Expand
National Institutes of Health

Related topics

Related topics

7 relations
Arachidonic Acid Metabolism PathwayCBR3 geneCytoplasmic matrixEnzyme Gene
Expand

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Evidence for association of SNPs in ABCB1 and CBR3, but not RAC2, NCF4, SLC28A3 or TOP2B, with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines.
AIMS Validation of associations for SNPs in RAC2, NCF4 and SLC28A3, identification of a novel association with a TOP2B SNP and… Expand
  • figure 1
  • table 1
  • table 3
  • figure 2
Highly Cited
2012
Highly Cited
2012
Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes--a report from the Children's Oncology Group.
PURPOSE Carbonyl reductases (CBRs) catalyze reduction of anthracyclines to cardiotoxic alcohol metabolites. Polymorphisms in CBR1… Expand
2011
2011
Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone.
Polycyclic aromatic hydrocarbons (PAHs) are suspect human lung carcinogens and can be metabolically activated to remote quinones… Expand
2010
2010
Naturally Occurring Variants of Human CBR3 Alter Anthracycline In Vitro Metabolism
Doxorubicin (DOX) and daunorubicin (DAUN) are anthracycline anticancer agents; however, considerable interpatient variability… Expand
  • table 1
  • table 2
  • figure 1
  • figure 2
  • table 3
2009
2009
Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.
Human carbonyl reductase is a member of the short-chain dehydrogenase/reductase (SDR) protein superfamily and is known to play an… Expand
  • table 2
  • figure 1
  • figure 3
  • figure 4
  • figure 5
Highly Cited
2008
Highly Cited
2008
Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline‐related congestive heart failure after childhood…
Exposure to anthracyclines as part of cancer therapy has been associated with the development of congestive heart failure (CHF… Expand
Highly Cited
2008
Highly Cited
2008
Genotype of human carbonyl reductase CBR3 correlates with doxorubicin disposition and toxicity
Objectives Doxorubicin is a cytotoxic drug with potential for severe myelosuppression that is highly variable and poorly… Expand
Highly Cited
2005
Highly Cited
2005
FUNCTIONAL SIGNIFICANCE OF A NATURAL ALLELIC VARIANT OF HUMAN CARBONYL REDUCTASE 3 (CBR3)
Human carbonyl reductase (CBR) activity accounts for a significant fraction of the metabolism of endogenous and xenobiotic… Expand
  • figure 1
  • table 1
  • table 2
  • figure 2
2004
2004
Carbonyl reduction of naltrexone and dolasetron by oxidoreductases isolated from human liver cytosol
The opioid receptor antagonist naltrexone and the antiemetic 5‐HT3 receptor antagonist dolasetron are ketonic drugs that are… Expand
2000
2000
Carbonyl reduction of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by cytosolic enzymes in human liver and lung.
The tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent pulmonary carcinogen… Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE