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Carbonyl Reductase [NADPH] 3

Known as: Carbonyl Reductase 3, NADPH-Dependent Carbonyl Reductase 3, EC 1.1.1.184 
Carbonyl reductase [NADPH] 3 (277 aa, ~31 kDa) is encoded by the human CBR3 gene. This protein plays a role in the reduction of metabolically active… Expand
National Institutes of Health

Papers overview

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2016
2016
AIMS Validation of associations for SNPs in RAC2, NCF4 and SLC28A3, identification of a novel association with a TOP2B SNP and… Expand
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Highly Cited
2012
Highly Cited
2012
PURPOSE Carbonyl reductases (CBRs) catalyze reduction of anthracyclines to cardiotoxic alcohol metabolites. Polymorphisms in CBR1… Expand
2011
2011
Polycyclic aromatic hydrocarbons (PAHs) are suspect human lung carcinogens and can be metabolically activated to remote quinones… Expand
2010
2010
Doxorubicin (DOX) and daunorubicin (DAUN) are anthracycline anticancer agents; however, considerable interpatient variability… Expand
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2009
2009
Human carbonyl reductase is a member of the short-chain dehydrogenase/reductase (SDR) protein superfamily and is known to play an… Expand
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Highly Cited
2008
Highly Cited
2008
Exposure to anthracyclines as part of cancer therapy has been associated with the development of congestive heart failure (CHF… Expand
Highly Cited
2008
Highly Cited
2008
Objectives Doxorubicin is a cytotoxic drug with potential for severe myelosuppression that is highly variable and poorly… Expand
Highly Cited
2005
Highly Cited
2005
Human carbonyl reductase (CBR) activity accounts for a significant fraction of the metabolism of endogenous and xenobiotic… Expand
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2004
2004
The opioid receptor antagonist naltrexone and the antiemetic 5‐HT3 receptor antagonist dolasetron are ketonic drugs that are… Expand
2000
2000
The tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent pulmonary carcinogen… Expand