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CBR3 gene

Known as: Carbonyl Reductase 3 Gene, short chain dehydrogenase/reductase family 21C, member 2, SDR21C2 
This gene plays a role in the reduction of carbonyl-containing compounds.
National Institutes of Health

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CBR3 wt Allele
Carbonyl Reductase [NADPH] 3Oxidation-ReductionQuinone Metabolismcarbonyl reductase (NADPH)

Papers overview

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2018
2018
LncRNA CBR3-AS1 predicts unfavorable prognosis and promotes tumorigenesis in osteosarcoma.
2018
2018
PlncRNA‐1 is overexpressed in retinoblastoma and regulates retinoblastoma cell proliferation and motility through modulating CBR3
PlncRNA‐1 has been suggested to function as an oncogenic role in prostate cancer, colorectal cancer, hepatocellular carcinoma… 
2011
2011
Studies on reduction of S-nitrosoglutathione by human carbonyl reductases 1 and 3.
2010
2010
A rapid, reproducible, on-the-fly orthogonal array optimization method for targeted protein quantification by LC/MS and its application for accurate and sensitive quantification of carbonyl…
Liquid chromatography (LC)/mass spectrometry (MS) in selected-reactions-monitoring (SRM) mode provides a powerful tool for… 
2010
2010
Naturally Occurring Variants of Human CBR3 Alter Anthracycline In Vitro Metabolism
Doxorubicin (DOX) and daunorubicin (DAUN) are anthracycline anticancer agents; however, considerable interpatient variability… 
Highly Cited
2008
Highly Cited
2008
Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline‐related congestive heart failure after childhood…
Exposure to anthracyclines as part of cancer therapy has been associated with the development of congestive heart failure (CHF… 
Highly Cited
2008
Highly Cited
2008
Genotype of human carbonyl reductase CBR3 correlates with doxorubicin disposition and toxicity
Objectives Doxorubicin is a cytotoxic drug with potential for severe myelosuppression that is highly variable and poorly… 
2007
2007
Photochemical reaction pathways of carbon tetrabromide in solution probed by picosecond X-ray diffraction.
We report a liquid-phase time-resolved X-ray diffraction study that resolves the molecular structures of the short-lived… 
Highly Cited
2005
Highly Cited
2005
FUNCTIONAL SIGNIFICANCE OF A NATURAL ALLELIC VARIANT OF HUMAN CARBONYL REDUCTASE 3 (CBR3)
Human carbonyl reductase (CBR) activity accounts for a significant fraction of the metabolism of endogenous and xenobiotic… 
2004
2004
PTEN M-CBR3, a Versatile and Selective Regulator of Inositol 1,3,4,5,6-Pentakisphosphate (Ins(1,3,4,5,6)P5)
The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumor suppressor is a phosphatidylinositol 3,4,5… 
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