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Effects of synthetic gestagens on fish reproduction.
TLDR
The effects of two progestins currently marketed in contraceptive formulations, levonorgestrel (LNG) and drospirenone (DRSP), were investigated in adult fathead minnows following an Organization for Economic Cooperation and Development 21-d fish reproduction screening assay draft protocol with additional end points. Expand
Carbonyl Reductase 1 Is a Predominant Doxorubicin Reductase in the Human Liver
TLDR
Results suggest that CBR1 is a predominant hepatic DOX reductase, and the variability in the CBR 1 expression may affect outcomes of therapies with DOX, as well as with otherCBR1 substrates. Expand
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.
TLDR
A functional subdivision of the SDR superfamily into at least 200 SDR families based upon hidden Markov models forms a suitable foundation for such a nomenclature system, which is presented in this paper using human SDRs as examples. Expand
Carbonyl Reductases and Pluripotent Hydroxysteroid Dehydrogenases of the Short-chain Dehydrogenase/reductase Superfamily
TLDR
The present review summarizes recent findings on carbonyl reductases and pluripotent HSDs of the SDR protein superfamily. Expand
Purification and characterization of oxidoreductases-catalyzing carbonyl reduction of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human liver cytosol
1. Four enzymes were purified to homogeneity from human liver cytosol and were demonstrated to be responsible for carbonyl reduction of the tobacco-specific nitrosamineExpand
Cytotoxic potency of H2O2 in cell cultures: impact of cell concentration and exposure time.
TLDR
The results indicate that the cytotoxic potency of H( 2)O(2) administered to cultured cells as a bolus is characterized by the AUC, which depends on its initial concentration, the ability of the cells to eliminate H(2]O( 2), and the cell concentration. Expand
Development of daunorubicin resistance in tumour cells by induction of carbonyl reduction.
TLDR
DRC resistance in human stomach carcinoma cells may appear as a result of an induction of metabolic DRC inactivation via carbonyl reduction to the less active 13-hydroxy metabolite DRCOL. Expand
PURIFICATION AND CHARACTERIZATION OF AKR1B10 FROM HUMAN LIVER: ROLE IN CARBONYL REDUCTION OF XENOBIOTICS
TLDR
Members of the aldo-keto reductase (AKR) superfamily have a broad substrate specificity in catalyzing the reduction of carbonyl group-containing xenobiotics and may play a role in the occurrence of chemoresistance of tumors toward carbonyL group-bearing cytostatic drugs. Expand
Enantioselectivity of carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone by tissue fractions from human and rat and by enzymes isolated from human liver.
TLDR
Experiments with 18beta-glycyrrhetinic acid, a potent inhibitor of 11 beta-HSD1, also indicated a minor or no role for 11beta-HSd1, and multiple enzymes seem to participate in NNK reduction in human and rat tissues. Expand
Human carbonyl reductases.
TLDR
The present review summarizes the current knowledge on these enzymes with special emphasis on their role as a defence system against toxicants, as well as their possible physiological function and medical application and their possible association with cancer. Expand
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