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Of the potent lipid inflammatory mediators comprising the cysteinyl leukotrienes (LTs; LTC4, LTD4, and LTE4), only LTE4 is stable… Expand The metabolism of arachidonic acid by either cyclooxygenase or lipoxygenase is believed to play an important role in… Expand Pulmonary fibrosis is characterized by the accumulation of fibroblasts and myofibroblasts. These cells may accumulate from three… Expand BACKGROUND
Oxygen free radicals are important components involved in the pathophysiological processes observed during ischemia… Expand Chronic hyperplastic eosinophilic sinusitis is an inflammatory disease that results in the accumulation of eosinophils… Expand BACKGROUND
Patients with asthma who have aspirin sensitivity have greater cysteinyl leukotriene production and greater airway… Expand The cysteinyl leukotrienes (cys-LTs) LTC4, LTD4, and LTE4 are a class of peptide-conjugated lipids formed from arachidonic acid… Expand Recent studies suggest that bone marrow (BM)-derived chemotactic mediators such as chemokines play key roles in hematopoietic… Expand Background Cysteinyl leukotrienes (CysLTs) have been implicated as important contributors in the pathophysiology of asthma and… Expand The cysteinyl leukotrienes—leukotriene C4(LTC4), leukotriene D4(LTD4) and leukotriene E4(LTE 4)—are important mediators of human… Expand