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Functional TRPV4 channels are expressed in human airway smooth muscle cells.
It is concluded that functional TRPV4 is expressed in human airway smooth muscle cells and may act as an osmolarity sensor in the airway.
Role of CXCR2 in cigarette smoke-induced lung inflammation.
- T. Thatcher, N. McHugh, R. Phipps
- Medicine, BiologyAmerican journal of physiology. Lung cellular and…
- 15 April 2005
Results demonstrate that inhibiting CXCR2 reduces neutrophilic inflammation and associated lung tissue damage due to acute cigarette smoke exposure.
Preclinical pharmacology of desloratadine, a selective and nonsedating histamine H1 receptor antagonist. 1st communication: receptor selectivity, antihistaminic activity, and antiallergenic effects.
- W. Kreutner, J. Hey, J. Anthes, A. Barnett, S. Young, S. Tozzi
- Medicine, BiologyArzneimittel-Forschung
- 27 December 2011
Preclinical studies provide evidence that desloratadine is an antihistaminic agent with a greater potency than loratadines and, together with results from numerous published studies, suggest an antiallergic effect of deslor atadine.
The pharmacology of SCH 50911: a novel, orally-active GABA-beta receptor antagonist.
- D. Bolser, D. Blythin, W. Kreutner
- Biology, ChemistryThe Journal of pharmacology and experimental…
- 1 September 1995
The pharmacology of SCH 50911 (+)-5,5-dimethyl-2-morpholineacetic acid hydrochloride), a structurally novel GABA-B receptor antagonist, was compared with CGP 35348, a moderately potent and selective GABA- B antagonist with acceptable in vivo activity.
Central antitussive activity of the NK1 and NK2 tachykinin receptor antagonists, CP‐99,994 and SR 48968, in the guinea‐pig and cat
- D. Bolser, F. DeGennaro, S. O'Reilly, R. Mcleod, J. Hey
- Medicine, BiologyBritish journal of pharmacology
- 1 May 1997
The antitussive activity and sites of action of the NK1 and NK2 tachykinin receptor antagonists, CP‐99,994, SR 48968, and the racemate, SR 48212A in the cat and guinea‐pig were investigated to determine the effective dose ratio (EDR) and intra‐arterial potencies of these compounds.
A Novel, Orally Active CXCR1/2 Receptor Antagonist, Sch527123, Inhibits Neutrophil Recruitment, Mucus Production, and Goblet Cell Hyperplasia in Animal Models of Pulmonary Inflammation
- R. Chapman, M. Minnicozzi, J. Hey
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 August 2007
Sch527123 may offer benefit for the treatment of inflammatory lung disorders in which pulmonary neutrophilia and mucus hypersecretion are important components of the underlying disease pathology.
The effect of codeine on the Urge-to-Cough response to inhaled capsaicin.
TRPV1 antagonists attenuate antigen-provoked cough in ovalbumin sensitized guinea pigs
It is concluded that TRPV1 channel activation may play role in cough mediated by antigen in sensitized guinea pigs and supports increasing evidence that TRpV1 may play a role in the generation of the cough response.
Influence of central antitussive drugs on the cough motor pattern.
Electromyograms of diaphragm and rectus abdominis muscles were recorded in anesthetized, spontaneously breathing cats to determine the effects of administration of centrally active antitussive drugs on the cough motor pattern.
Aducanumab, gantenerumab, BAN2401, and ALZ-801—the first wave of amyloid-targeting drugs for Alzheimer’s disease with potential for near term approval
- M. Tolar, S. Abushakra, J. Hey, A. Porsteinsson, M. Sabbagh
- Biology, MedicineAlzheimer's Research & Therapy
- 12 August 2020
The most advanced selective anti-oligomer agent is ALZ-801, an optimized oral prodrug of tramiprosate, which demonstrated efficacy in homozygous APOE4/4 AD subjects, and will be evaluated in a phase 3 trial in patients with early AD.