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A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia.
TLDR
Findings show that the -141C Ins/Del may be a functional polymorphism in the 5'-promoter region of DRD2 and may affect the susceptibility to schizophrenia. Expand
Discovery of the Presence and Functional Expression of Cannabinoid CB2 Receptors in Brain
TLDR
It is demonstrated that CB2 CBrs and their gene transcripts are widely distributed in the brain, contrary to the prevailing view that CB 2 CBrs are restricted to peripheral tissues and predominantly in immune cells. Expand
Human cannabinoid receptor 1: 5′ exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse
TLDR
Improved definition of the human CB1/Cnr1 locus and its variants is reported, finding that post-mortem brain samples of heterozygous individuals contain less mRNA transcribed from the TAG alleles than from other CB1 or Cnr1 haplotypes, andCB1/ Cnr 1 genomic variation thus appears to play roles in human addiction vulnerability. Expand
Brain Neuronal CB2 Cannabinoid Receptors in Drug Abuse and Depression: From Mice to Human Subjects
TLDR
The functional expression of CB2-Rs in brain that may provide novel targets for the effects of cannabinoids in depression and substance abuse disorders beyond neuro-immunocannabinoid activity is demonstrated. Expand
Methylenetetrahydrofolate reductase variant and schizophrenia/depression.
TLDR
The data suggest associations of the MTHFR gene variant with schizophrenia and depression in the Japanese are higher than previously thought. Expand
Association of dopamine D2 receptor molecular variant with schizophrenia
TLDR
The patients with Cys 311 showed significantly less severe thought disorder and negative symptoms of schizophrenia than those without Cys311 and may be a genetic risk factor for some types of schizophrenia. Expand
A genetic polymorphism in the promoter region of DRD4 associated with expression and schizophrenia.
TLDR
Although the association is weak and should be considered tentative until other studies replicate it, this polymorphism provides a tool with the potential to examine whether DRD4 is related to susceptibility to and neuroleptic response in schizophrenia. Expand
An association study of asthma and total serum immunoglobin E levels for Toll‐like receptor polymorphisms in a Japanese population
TLDR
The hygiene hypothesis, which states that exposure to specific infections or endotoxins during infancy drives the maturing immune system towards a Th1 phenotype and away from the Th2 phenotype, is supported. Expand
Identification of a polymorphism in the promoter region of DRD4associated with the human novelty seeking personality trait
TLDR
A contribution of dopamine D4 receptor availability to individual differences in Novelty Seeking behavior is suggested. Expand
Brain Cannabinoid CB2 Receptor in Schizophrenia
TLDR
Findings indicate an increased risk of schizophrenia for people with low CB2 receptor function, as well as nominally significant associations between schizophrenia and two SNPs. Expand
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