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CYP1B1 protein, human

Known as: CYPIB1, EC 1.14.14.1, Cytochrome P450 1B1 
Cytochrome P450 1B1 (543 aa, ~61 kDa) is encoded by the human CYP1B1 gene. This protein plays a role in the metabolism of steroids and xenobiotics.
National Institutes of Health

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13 relations
CYP1B1 geneEnzyme GeneEye DevelopmentHemeproteins

Broader (1)

cytochrome P-450 CYP1B1

Papers overview

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Highly Cited
2013
Highly Cited
2013
Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension
Aims Pulmonary arterial hypertension (PAH) occurs more frequently in women than men. Oestrogen and the oestrogen-metabolising… 
Highly Cited
2007
Highly Cited
2007
Cytochrome P450 1B1-mediated estrogen metabolism results in estrogen-deoxyribonucleoside adduct formation.
The oxidative metabolism of estrogens has been implicated in the development of breast cancer; yet, relatively little is known… 
Highly Cited
2005
Highly Cited
2005
Cytochrome P450 1B1 and Catechol-O-Methyltransferase Genetic Polymorphisms and Breast Cancer Risk in Chinese Women: Results from the Shanghai Breast Cancer Study and a Meta-analysis
Cytochrome P450 1B1 (CYP1B1) and catechol-O-methyltransferase (COMT) are important estrogen-metabolizing enzymes and, thus… 
Highly Cited
2004
Highly Cited
2004
GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high‐risk population
Tobacco smoking and occupation are major risk factors of bladder cancer via exposure to polycyclic aromatic hydrocarbons (PAHs… 
Highly Cited
2004
Highly Cited
2004
Tobacco smoke induces CYP1B1 in the aerodigestive tract.
Several members of the P450 family, including cytochrome P450 1B1 (CYP1B1), can convert tobacco smoke (TS) procarcinogens… 
Highly Cited
2003
Highly Cited
2003
Novel cytochrome P450 1B1 (CYP1B1) mutations in patients with primary congenital glaucoma in France
The CYP1B1 gene (GenBank: U56438), a member of the cytochrome P450 gene family, has been shown to be mutated in patients with… 
Highly Cited
2003
Highly Cited
2003
Cytochrome P450 1B1 gene polymorphisms and postmenopausal breast cancer risk.
Cytochrome P450 1B1 (CYP1B1) is active in the metabolism of estrogens to reactive catechols and of different procarcinogens… 
Highly Cited
2002
Highly Cited
2002
Cytochrome P450 CYP1B1 and catechol O-methyltransferase (COMT) genetic polymorphisms and breast cancer susceptibility in a Turkish population
Abstract. Epidemiological studies indicate that most risk factors for breast cancer are related to reproductive and hormonal… 
Highly Cited
2000
Highly Cited
2000
Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer.
Cytochrome P450 1B1 (CYP1B1) participates in the metabolic activation of a number of procarcinogens including benzo[a]pyrene and… 
Highly Cited
2000
Highly Cited
2000
Trans-resveratrol modulates the catalytic activity and mRNA expression of the procarcinogen-activating human cytochrome P450 1B1.
The present study was performed to determine if trans-resveratrol (3,5,4'-trihydroxy-trans-stilbene) modulates the catalytic… 
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