Cytochrome P450 1B1-mediated estrogen metabolism results in estrogen-deoxyribonucleoside adduct formation.

@article{Belous2007CytochromeP1,
  title={Cytochrome P450 1B1-mediated estrogen metabolism results in estrogen-deoxyribonucleoside adduct formation.},
  author={Alexandra R. Belous and David L. Hachey and Sheila Dawling and Nady Roodi and Fritz F Parl},
  journal={Cancer research},
  year={2007},
  volume={67 2},
  pages={
          812-7
        }
}
The oxidative metabolism of estrogens has been implicated in the development of breast cancer; yet, relatively little is known about the mechanism by which estrogens cause DNA damage and thereby initiate mammary carcinogenesis. To determine how the metabolism of the parent hormone 17beta-estradiol (E2) leads to the formation of DNA adducts, we used the recombinant, purified phase I enzyme, cytochrome P450 1B1 (CYP1B1), which is expressed in breast tissue, to oxidize E2 in the presence of 2… CONTINUE READING

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