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CXCR4 protein, human

Known as: LAP-3, CXC-R4, Lipopolysaccharide-Associated Protein 3 
C-X-C chemokine receptor type 4 (352 aa, ~40 kDa) is encoded by the human CXCR4 gene. This protein is involved in the stimulation of mitogenic… 
National Institutes of Health

Related topics

Related topics

30 relations
ApoptosisAxon GuidanceC-X-C motif chemokine 12 receptor activityCCR5 Signaling Pathway

Broader (1)

CXCR4 Receptors

Papers overview

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Highly Cited
2009
Highly Cited
2009
Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model.
OBJECTIVE Stromal cell-derived factor 1 (SDF-1; CXCL12/pre-B cell growth-stimulating factor) is a dominant chemokine in bone… 
Highly Cited
2009
Highly Cited
2009
AMD3100 Is a CXCR7 Ligand with Allosteric Agonist Properties
The bicyclam AMD3100 is known as a small synthetic inhibitor of the CXCL12-binding chemokine receptor CXCR4. Here, we show that… 
Highly Cited
2006
Highly Cited
2006
Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion
Hypoxia and hypoxia-inducible factor-1 (HIF-1) play a critical role in glioblastoma multiforme (GBMs). CXCR4 is involved in… 
Highly Cited
2005
Highly Cited
2005
Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival.
PURPOSE Liver metastasis is the predominant cause of colorectal cancer (CRC) related mortality. Chemokines, soluble factors that… 
Highly Cited
2004
Highly Cited
2004
Involvement of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1alpha in breast cancer cell migration through human brain microvascular endothelial cells.
In this study, we have characterized the signaling pathways mediated by CXCR4 in breast cancer cells and its role in breast… 
Highly Cited
2003
Highly Cited
2003
Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease
WHIM syndrome is an immunodeficiency disease characterized by neutropenia, hypogammaglobulinemia and extensive human… 
Highly Cited
2003
Highly Cited
2003
A zebrafish homologue of the chemokine receptor Cxcr4 is a germ-cell guidance receptor
Germ cells preserve an individual's genetic information and transmit it to the next generation. Early in development germ cells… 
Highly Cited
2001
Highly Cited
2001
Matrix Metalloproteinase Activity Inactivates the CXC Chemokine Stromal Cell-derived Factor-1*
Chemokines provide directional cues for leukocyte migration and activation that are essential for normal leukocytic trafficking… 
Review
1998
Review
1998
Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4
Highly Cited
1997
Highly Cited
1997
CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons
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