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Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells.
TLDR
This is the first report demonstrating that ghrelin functions as a key signal, coupling the metabolic axis to the immune system, and supporting the potential use of gh Relin and GHS-R agonists in the management of disease-associated cachexia.
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AGEMAP: A Gene Expression Database for Aging in Mice
TLDR
The AGEMAP (Atlas of Gene Expression in Mouse Aging Project) gene expression database is presented, which is a resource that catalogs changes in gene expression as a function of age in mice and finds great heterogeneity in the amount of transcriptional changes with age in different tissues.
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Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4
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Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo
TLDR
It is reported that IP-10 is a potent inhibitor of angiogenesis in vivo and the possibility that IP -10 may participate in the regulation ofAngiogenesis during inflammation and tumorigenesis is raised.
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The origins of age-related proinflammatory state.
TLDR
Part of the "proinflammatory state" in older persons is related to the high prevalence of cardiovascular risk factor and morbidity.
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The Wnt5A/Protein Kinase C Pathway Mediates Motility in Melanoma Cells via the Inhibition of Metastasis Suppressors and Initiation of an Epithelial to Mesenchymal Transition*
TLDR
RWnt5A treatment increases Snail and vimentin expression, and decreases E-cadherin, even in the presence of dominant-negativeTCF4, suggesting that this activation is independent of Wnt/β-catenin signaling.
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CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons
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Identification of Defensin-1, Defensin-2, and CAP37/Azurocidin as T-cell Chemoattractant Proteins Released from Interleukin-8-stimulated Neutrophils (*)
TLDR
The antimicrobial proteins, CAP37/azurocidin and defensins H NP-1 and HNP-2, are identified as potent neutrophil-derived chemoattractants for T-cells, which represent primordial antimicrobial peptides which may have evolved into acute inflammatory cell-derived signals that mobilize immunocompetent T- cells and other inflammatory cells.
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Evidence for miR‐181 involvement in neuroinflammatory responses of astrocytes
TLDR
It is shown that the miR‐181 family is developmentally regulated and present in high amounts in astrocytes compared to neurons, and further understanding of the role of miR-181 in inflammatory events and CNS injury could lead to novel approaches for the treatment of CNS disorders with an inflammatory component.
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Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility
TLDR
Serial analysis of gene expression followed by pathway analysis implicated the tight junction protein claudin-1 (CLDN1) in melanoma progression, as transient transfection of melanoma cells with CLDN1 increased metalloproteinase 2 secretion and activation, and subsequently, motility of melanomas cells as demonstrated by wound-healing assays.
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