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Cullin 4B (CUL4B) is a scaffold protein that assembles cullin-RING ubiquitin ligase (E3) complexes. Recent studies have revealed… Expand Previous reports showed that chromatin-associated PCNA couples DNA replication with Cul4-DDB1Cdt2-dependent proteolysis of the… Expand Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) has been shown to cause G2 cell cycle arrest in human cells by… Expand Cullin-based E3 ligases are a large family of multi-subunit ubiquitin ligases with diverse cellular functions, including the… Expand Posttranslational histone modifications play important roles in transcription and other chromatin-based processes. Compared to… Expand The DDB1-Cul4A ubiquitin ligase complex promotes protein ubiquitination in diverse cellular functions and is reprogrammed by the… Expand As erythroid progenitors differentiate into precursors and finally mature red blood cells, lineage-specific genes are induced… Expand Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse… Expand Arabidopsis thaliana De-etiolated-1 (AtDET1) is a highly conserved protein, with orthologs in vertebrate and invertebrate… Expand This review summarizes recent advances concerning the Nedd8 regulatory pathway in four areas. One, substantial progress has been… Expand