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CUL4A gene

Known as: CUL4A, CULLIN 4A, Cullin 4A Gene 
This gene is involved in protein degradation. It also plays a role in cell cycle arrest and DNA repair.
National Institutes of Health

Related topics

Related topics

4 relations
CUL4B geneProtein Degradation, RegulatoryUbiquitinationcullin 4A

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Reduced miR-363-3p expression in non-small cell lung cancer is associated with gemcitabine resistance via targeting of CUL4A.
OBJECTIVE Accumulating evidence has suggested that aberrant expression of microRNAs (miRNAs) is associated with non-small cell… 
2018
2018
Structural basis for Cullins and RING component inhibition: Targeting E3 ubiquitin pathway conductors for cancer therapeutics.
2016
2016
Aberrant Expression of CUL4A Is Associated with IL-6/ STAT3 Activation in Colorectal Cancer Progression.
Review
2014
Review
2014
Monitoring regulation of DNA repair activities of cultured cells in-gel using the comet assay
Base excision repair (BER) is the predominant cellular mechanism by which human cells repair DNA base damage, sites of base loss… 
2013
2013
Analysis of DNA Repair–Related Genes in Breast Cancer Reveals CUL4A Ubiquitin Ligase as a Novel Biomarker of Trabectedin Response
Trabectedin is more active in nucleotide excision repair (NER)-efficient and homologous recombination repair (HRR)-deficient… 
2012
2012
Orc2 protects ORCA from ubiquitin-mediated degradation
Origin recognition complex (ORC) is highly dynamic, with several ORC subunits getting posttranslationally modified by… 
2011
2011
Transgenic mice for cre‐inducible overexpression of the Cul4A gene
The Cullin 4A(Cul4A) gene is important in cell survival, development, growth, and cell cycle control and is amplified in breast… 
2009
2009
MEPE/OF45 protects cells from DNA damage induced killing via stabilizing CHK1
Matrix extracellular phosphoglycoprotein/osteoblast factor 45 (MEPE/OF45) was cloned in 2000 with functions related to bone… 
2007
2007
DDB1 gene disruption causes a severe growth defect and apoptosis in chicken DT40 cells.
2007
2007
Cul4A is required for hematopoietic stem-cell engraftment and self-renewal.
Several hematopoietic stem-cell (HSC) regulators are controlled by ubiquitin-mediated proteolysis, so the ubiquitin pathway might… 
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