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Cleavage-mediated Activation of Chk1 during Apoptosis*
TLDR
It is shown that Chk1 is activated by caspase-mediated cleavage during apoptosis and might be implicated in enhancing apoptotic reactions rather than attenuating the ATR-Chk1 pathway.
Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin
TLDR
Results show that U BR5 downregulates proapoptotic MOAP-1 and suggest that UBR5 can confer cisplatin resistance in ovarian cancer, which may be an attractive therapeutic target for ovarian cancer treatment.
Spironolactone‐induced XPB degradation depends on CDK7 kinase and SCFFBXL18 E3 ligase
TLDR
It is found that the Ser90 residue of XPB is essential for the chemical‐induced destabilization, which led to a model that spironolactone may trigger the phosphorylation ofXPB at Ser90 by CDK7, which promotes the recognition and polyubiquitination of XPBs by SCFFBXL18 for proteasomal degradation.
Fatty Acid Synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death
TLDR
It is shown that the initiator caspase-2 is required for robust death of ovarian cancer cells induced by FASN inhibitors, placing mTOR as a novel upstream regulator of caspasing-2 and supporting the possibility of manipulating mTOR to enhance caspases-2 activation in ovarian cancer.
A Network of Substrates of the E3 Ubiquitin Ligases MDM2 and HUWE1 Control Apoptosis Independently of p53
TLDR
Findings demonstrate broader, p53-independent roles for MDM2 and HUWE1 in apoptosis and specifically suggest the potential for therapy directed againstMDM2 to overcome lapatinib resistance.
A Network of Substrates of the E 3 Ubiquitin Ligases MDM 2 and HUWE 1 Control Apoptosis Independently of p 53
htp:// D ow nladed from In the intrinsic pathway of apoptosis, cell-damaging signals promote the release of cytochrome c from mitochondria, triggering activation of the Apaf-1 and caspase-9
Metabolic Regulation of Apoptosis in Cancer.
TLDR
How cellular apoptosis is regulated and how metabolism can influence the signaling pathways leading to apoptosis are reviewed, especially focusing on how glucose and lipid metabolism are altered in cancer cells and how these alterations can impact the apoptotic pathways.
Rsk‐mediated phosphorylation and 14‐3‐3ε binding of Apaf‐1 suppresses cytochrome c‐induced apoptosis
TLDR
A mechanism for the inhibition of cytochrome c‐induced caspase activation by MAPK signalling is described, identifying a novel mode of apoptotic regulation exerted through Apaf‐1 phosphorylation by the 90‐kDa ribosomal S6 kinase (Rsk).
Dimer‐specific immunoprecipitation of active caspase‐2 identifies TRAF proteins as novel activators
TLDR
Trait necrosis factor receptor‐associated factor 2 (TRAF2) positively regulates caspase‐2 activation and consequent cell death by driving its activation through dimer‐stabilizing ubiquitylation.
DDB1 gene disruption causes a severe growth defect and apoptosis in chicken DT40 cells.
TLDR
The results demonstrate that the D DB1 gene is indispensable for cell viability in higher vertebrates and this conditional DDB1-knockout clone would be highly useful for the functional analysis of DDB 1.
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