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cullin 4A

Known as: Cullin Homolog 4A, CUL-4A, CUL4A 
Cullin-4A (759 aa, ~88 kDa) is encoded by the human CUL4A gene. This protein is involved in both DNA repair and protein ubiquitination.
National Institutes of Health

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8 relations
CUL4A geneCullin Family ProteinGenes, RegulatorHomo sapiens

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Reduced miR-363-3p expression in non-small cell lung cancer is associated with gemcitabine resistance via targeting of CUL4A.
OBJECTIVE Accumulating evidence has suggested that aberrant expression of microRNAs (miRNAs) is associated with non-small cell… 
2019
2019
A feedback regulation of CREB activation through the CUL4A and ERK signaling
CUL4A; an E3 ubiquitin ligase is involved in the degradation of negative regulators of cell cycle such as p21, p27, p53, etc… 
2016
2016
Insights into significant pathways and gene interaction networks in peripheral blood mononuclear cells for early diagnosis of hepatocellular carcinoma.
BACKGROUND Early diagnosis of hepatocellular cancer (HCC) significantly helps improve patient survival. However, high specific… 
2016
2016
Aberrant Expression of CUL4A Is Associated with IL-6/ STAT3 Activation in Colorectal Cancer Progression.
2015
2015
Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex
Lgl is a conserved tumor suppressor suggested to be involved in cell polarity regulation and suppression of cell proliferation… 
2013
2013
Analysis of DNA Repair–Related Genes in Breast Cancer Reveals CUL4A Ubiquitin Ligase as a Novel Biomarker of Trabectedin Response
Trabectedin is more active in nucleotide excision repair (NER)-efficient and homologous recombination repair (HRR)-deficient… 
2008
2008
Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome
BackgroundCullin-RING ubiquitin E3 ligases (CRLs) are regulated by modification of an ubiquitin-like protein, Nedd8 (also known… 
2008
2008
Muc1 oncoprotein suppresses activation of the ARF-MDM2-p53 pathway
The MUC1 oncoprotein interacts with the c-Abl tyrosine kinase and blocks nuclear targeting of c-Abl in the apoptotic response to… 
2007
2007
Cul4A is required for hematopoietic stem-cell engraftment and self-renewal.
Several hematopoietic stem-cell (HSC) regulators are controlled by ubiquitin-mediated proteolysis, so the ubiquitin pathway might… 
Highly Cited
2001
Highly Cited
2001
UV-damaged DNA-binding Proteins Are Targets of CUL-4A-mediated Ubiquitination and Degradation*
Cul-4A, which encodes a member of the cullin family subunit of ubiquitin-protein ligases, is expressed at abnormally high levels… 
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