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cullin 4A

Known as: Cullin Homolog 4A, CUL-4A, CUL4A 
Cullin-4A (759 aa, ~88 kDa) is encoded by the human CUL4A gene. This protein is involved in both DNA repair and protein ubiquitination.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Restriction factors, such as the retroviral complementary DNA deaminase APOBEC3G, are cellular proteins that dominantly block… Expand
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Highly Cited
2010
Highly Cited
2010
Thalidomide Teratogenicity Target In the late 1950s and early 1960s, thalidomide was prescribed to pregnant women as a cure for… Expand
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Highly Cited
2006
Highly Cited
2006
Protein ubiquitination is a common form of post-translational modification that regulates a broad spectrum of protein substrates… Expand
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Highly Cited
2006
Highly Cited
2006
Xeroderma pigmentosum (XP) complementation group E gene product, damaged DNA-binding protein 2 (DDB2), is a subunit of the DDB… Expand
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Highly Cited
2006
Highly Cited
2006
The CUL4–DDB1–ROC1 ubiquitin E3 ligase regulates cell-cycle progression, replication and DNA damage response. However, the… Expand
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Highly Cited
2004
Highly Cited
2004
Arabidopsis thaliana De-etiolated-1 (AtDET1) is a highly conserved protein, with orthologs in vertebrate and invertebrate… Expand
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Highly Cited
2001
Highly Cited
2001
Cul-4A, which encodes a member of the cullin family subunit of ubiquitin-protein ligases, is expressed at abnormally high levels… Expand
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Highly Cited
1999
Highly Cited
1999
Recently we found that NEDD8, a ubiquitin-like protein, was linked covalently to human cullin-4A (abbreviated Cul-4A) by a new… Expand
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Highly Cited
1999
Highly Cited
1999
The damaged DNA-binding protein (DDB) is believed to be involved in DNA repair, and it has been linked to the repair deficiency… Expand
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Highly Cited
1998
Highly Cited
1998
NEDD8 is a ubiquitin (Ub)-like protein. Here we report a novel ubiquitinylation-related pathway for modification by NEDD8. NEDD8… Expand
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