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Curcumin, a polyphenol found in the rhizomes of Curcuma longa, improves obesity-associated inflammation and diabetes in obese… Expand We have used RNA interference previously to demonstrate that G protein-coupled receptor kinase 2 (GRK2) regulates endogenously… Expand Trisubstituted pyrrole inhibitors of the essential coccidian parasite cGMP dependent protein kinase (PKG) block parasite invasion… Expand FADD is essential for death receptor (DR)-induced apoptosis. However, it is also critical for cell cycle progression and… Expand Wnt regulation of beta-catenin degradation is essential for development and carcinogenesis. beta-catenin degradation is initiated… Expand Casein kinase I (CKI) was recently reported as a positive regulator of Wnt signaling in vertebrates and Caenorhabditis elegans… Expand The Alzheimer's disease-linked gene presenilin 1 (PS1) is required for intramembrane proteolysis of APP and Notch. In addition… Expand Alzheimer's Disease (AD) is a progressive neurodegenerative disorder involving select neurons of the hippocampus, neocortex, and… Expand T cell activation requires the import of NF-AT transcription factors to the nucleus, a process promoted by calcineurin-dependent… Expand The casein kinase I family of serine/threonine protein kinases is highly conserved from yeast to humans. Until only recently… Expand