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Experimental validation of a predicted feedback loop in the multi-oscillator clock of Arabidopsis thaliana
Our computational model of the circadian clock comprised the feedback loop between LATE ELONGATED HYPOCOTYL (LHY), CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and TIMING OF CAB EXPRESSION 1 (TOC1), and aExpand
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The ELF4 gene controls circadian rhythms and flowering time in Arabidopsis thaliana
Many plants use day length as an environmental cue to ensure proper timing of the switch from vegetative to reproductive growth. Day-length sensing involves an interaction between the relative lengthExpand
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Extension of a genetic network model by iterative experimentation and mathematical analysis
Circadian clocks involve feedback loops that generate rhythmic expression of key genes. Molecular genetic studies in the higher plant Arabidopsis thaliana have revealed a complex clock network. TheExpand
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The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops
Circadian clocks synchronise biological processes with the day/night cycle, using molecular mechanisms that include interlocked, transcriptional feedback loops. Recent experiments identified theExpand
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Mapping the Core of the Arabidopsis Circadian Clock Defines the Network Structure of the Oscillator
  • W. Huang, P Pérez-García, +4 authors P. Mas
  • Biology, Medicine
  • Science
  • 6 April 2012
Tic TOC1 Plant Clock The molecular clocks intertwined with cellular physiology regulate daily cycles. In plants, these circadian rhythms affect processes as diverse as carbon metabolism and leafExpand
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FKF1 Conveys Timing Information for CONSTANS Stabilization in Photoperiodic Flowering
Spring Into Flower In spring, plants respond to increasing day length and shifts in the spectrum of solar irradiance by releasing the flowering induction pathway, which includes expression of theExpand
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FLOWERING LOCUS C Mediates Natural Variation in the High-Temperature Response of the Arabidopsis Circadian Clock[W]
Temperature compensation contributes to the accuracy of biological timing by preventing circadian rhythms from running more quickly at high than at low temperatures. We previously identifiedExpand
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Modelling genetic networks with noisy and varied experimental data: the circadian clock in Arabidopsis thaliana.
Circadian clocks in all organisms include feedback loops that generate rhythmic expression of key genes. We model the first such loop proposed for the clock of Arabidopsis thaliana, the experimentalExpand
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Peroxiredoxins are conserved markers of circadian rhythms
Cellular life emerged ∼3.7 billion years ago. With scant exception, terrestrial organisms have evolved under predictable daily cycles owing to the Earth’s rotation. The advantage conferred onExpand
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Circadian clock mutants in Arabidopsis identified by luciferase imaging
The cycling bioluminescence of Arabidopsis plants carrying a firefly luciferase fusion construct was used to identify mutant individuals with aberrant cycling patterns. Both long- and short-periodExpand
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