Skip to search formSkip to main contentSkip to account menu

CLEC7A gene

Known as: hDectin-1, C-type Lectin Domain Family 7, Member A Gene, DECTIN 1 
This gene plays a role in the innate immune response.
National Institutes of Health

Related topics

Related topics

4 relations
CLEC4A geneCLEC7A protein, humanImmune System Processesdectin 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
The role of Syk/CARD9 coupled C-type lectins in antifungal immunity
Fungal infections are affecting an increasing number of people, and the failure of current therapies in treating systemic… 
Highly Cited
2009
Highly Cited
2009
Human dectin-1 deficiency and mucocutaneous fungal infections.
Mucocutaneous fungal infections are typically found in patients who have no known immune defects. We describe a family in which… 
Highly Cited
2009
Highly Cited
2009
Early stop polymorphism in human DECTIN-1 is associated with increased candida colonization in hematopoietic stem cell transplant recipients.
Background. Intensive treatment of hematological malignancies with hematopoietic stem cell transplantation (HSCT) is accompanied… 
Highly Cited
2008
Highly Cited
2008
Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses.
The C-type lectin receptor dectin-1 functions as a pattern recognition receptor for beta-glucans and signals via Syk kinase but… 
Highly Cited
2008
Highly Cited
2008
Dectin‐1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages
The β‐glucan receptor dectin‐1 and Toll‐like receptors TLR2 and TLR4 are the main receptors for recognition of Candida albicans… 
Highly Cited
2008
Highly Cited
2008
Dynamic, Morphotype-Specific Candida albicans β-Glucan Exposure during Infection and Drug Treatment
Candida albicans, a clinically important dimorphic fungal pathogen that can evade immune attack by masking its cell wall β-glucan… 
Highly Cited
2006
Highly Cited
2006
The beta-glucan receptor dectin-1 functions together with TLR2 to mediate macrophage activation by mycobacteria.
Pattern recognition receptors (PRRs) play an essential role in a macrophage's response to mycobacterial infections. However, how… 
Highly Cited
2006
Highly Cited
2006
Ligands for the β-Glucan Receptor, Dectin-1, Assigned Using “Designer” Microarrays of Oligosaccharide Probes (Neoglycolipids) Generated from Glucan Polysaccharides*
Dectin-1 is a C-type lectin-like receptor on leukocytes that mediates phagocytosis and inflammatory mediator production in innate… 
Highly Cited
2004
Highly Cited
2004
The Role of SIGNR1 and the β-Glucan Receptor (Dectin-1) in the Nonopsonic Recognition of Yeast by Specific Macrophages1
We recently demonstrated that the β-glucan receptor Dectin-1 (βGR) was the major nonopsonic β-glucan receptor on macrophages (M… 
Highly Cited
2001
Highly Cited
2001
Characterization of the Human β-Glucan Receptor and Its Alternatively Spliced Isoforms*
β-1,3-d-Glucans are biological response modifiers with potent effects on the immune system. A number of receptors are thought to… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)