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dectin 1

Known as: dectin-1 
 
National Institutes of Health

Related topics

Related topics

3 relations
CLEC7A geneCLEC7A protein, human

Broader (1)

Lectins, C-Type

Papers overview

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Highly Cited
2012
Highly Cited
2012
The β-Glucan Receptor Dectin-1 Promotes Lung Immunopathology during Fungal Allergy via IL-22
Sensitization to fungi, such as the mold Aspergillus fumigatus, is increasingly becoming linked with asthma severity. We have… Expand
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Highly Cited
2011
Highly Cited
2011
Activation of the innate immune receptor Dectin-1 upon formation of a “phagocytic synapse”
Innate immune cells must be able to distinguish between direct binding to microbes and detection of components shed from the… Expand
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Highly Cited
2008
Highly Cited
2008
Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages.
The beta-glucan receptor dectin-1 and Toll-like receptors TLR2 and TLR4 are the main receptors for recognition of Candida… Expand
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Highly Cited
2006
Highly Cited
2006
Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance.
Emerging evidence suggests critical roles for APCs in suppressing immune responses. Here, we show that zymosan, a stimulus for… Expand
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Highly Cited
2005
Highly Cited
2005
The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus
Alveolar macrophages represent a first-line innate host defense mechanism for clearing inhaled Aspergillus fumigatus from the… Expand
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Highly Cited
2005
Highly Cited
2005
A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice
A combination of genetic and environmental factors can cause autoimmune disease in animals. SKG mice, which are genetically prone… Expand
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Highly Cited
2005
Highly Cited
2005
Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production.
Dectin-1 is a lectin receptor for beta-glucan that is important for innate macrophage recognition of fungi and contributes to… Expand
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Highly Cited
2003
Highly Cited
2003
Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2
Toll-like receptors (TLRs) mediate recognition of a wide range of microbial products including lipopolysaccharides, lipoproteins… Expand
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Highly Cited
2003
Highly Cited
2003
Alveolar Macrophage–mediated Killing of Pneumocystis carinii f. sp. muris Involves Molecular Recognition by the Dectin-1 β-Glucan Receptor
Innate immune mechanisms against Pneumocystis carinii, a frequent cause of pneumonia in immunocompromised individuals, are not… Expand
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Highly Cited
2002
Highly Cited
2002
Dectin-1 Is A Major β-Glucan Receptor On Macrophages
Zymosan is a β-glucan– and mannan-rich particle that is widely used as a cellular activator for examining the numerous responses… Expand
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