CLEC7A protein, human

Known as: hDectin-1, C-type lectin domain family 7, member A, human, Dectin 1 
C-type lectin domain family 7 member A (247 aa, ~28 kDa) is encoded by the human CLEC7A gene. This protein plays a role in the innate immune response… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2018
05101520002018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
The intestinal microflora, typically equated with bacteria, influences diseases such as obesity and inflammatory bowel disease… (More)
Is this relevant?
Highly Cited
2010
Highly Cited
2010
The C-type lectin receptor Dectin-1 plays a pivotal role in antifungal immunity. In this study, the recently characterized human… (More)
  • table 1
  • figure 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Immune suppression increases the incidence of invasive fungal infections, particularly those caused by the opportunistic mold… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Dectin-1 is a fungal pattern recognition receptor that binds to beta-glucans and triggers cytokine production by facilitating… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
The two lectin receptors, CLEC-2 and Dectin-1, have been shown to signal through a Syk-dependent pathway, despite the presence of… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Antigen presenting cells recognize pathogens via pattern recognition receptors (PRR), which upon ligation transduce intracellular… (More)
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Dectin-1 is a C-type lectin-like receptor on leukocytes that mediates phagocytosis and inflammatory mediator production in innate… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Dectin-1 is a lectin receptor for beta-glucan that is important for innate macrophage recognition of fungi and contributes to… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2005
Highly Cited
2005
We identified the C-type-lectin-like receptor, Dectin-1, as the major receptor for fungal beta-glucans on murine macrophages and… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Innate immune mechanisms against Pneumocystis carinii, a frequent cause of pneumonia in immunocompromised individuals, are not… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?