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CLCA2 protein, human

Known as: Calcium-Sensitive Chloride Channel 2, hCLCA2, CaCC-3 
Calcium-activated chloride channel regulator 2 (943 aa, ~104 kDa) is encoded by the human CLCA2 gene. This protein is involved in chloride ion… Expand
National Institutes of Health

Related topics

Related topics

21 relations
CLCA2 geneCLCA4 geneCellular MembraneCystic Fibrosis
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Broader (1)

Chloride Channels

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Loss of breast epithelial marker hCLCA2 promotes epithelial to mesenchymal transition and indicates higher risk of metastasis
Transition between epithelial and mesenchymal states is a feature of both normal development and tumor progression. We report… Expand
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2009
2009
hCLCA2 Is a p53-Inducible Inhibitor of Breast Cancer Cell Proliferation.
hCLCA2 is frequently down-regulated in breast cancer and is a candidate tumor suppressor gene. We show here that the hCLCA2 gene… Expand
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Highly Cited
2004
Highly Cited
2004
The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis
To determine whether the CLCA gene family of calcium-activated chloride channels is a modulator of the basic defect of cystic… Expand
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Highly Cited
2004
Highly Cited
2004
CLCA2 tumour suppressor gene in 1p31 is epigenetically regulated in breast cancer
The calcium-activated chloride channel gene family is clustered in the 1p31 region, which is frequently deleted in sporadic… Expand
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Highly Cited
2003
Highly Cited
2003
Modulation of Ca2+-Activated Cl− Secretion by Basolateral K+ Channels in Human Normal and Cystic Fibrosis Airway Epithelia
Human airway epithelia express Ca2+-activated Cl− channels (CaCC) that are activated by extracellular nucleotides (ATP and UTP… Expand
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Highly Cited
2003
Highly Cited
2003
The Interacting Binding Domains of the β4 Integrin and Calcium-activated Chloride Channels (CLCAs) in Metastasis*
CLCA (chloride channel, calcium-activated) proteins are novel pulmonary vascular addresses for blood-borne, lung-metastatic… Expand
Highly Cited
2001
Highly Cited
2001
The Breast Cancer β4 Integrin and Endothelial Human CLCA2 Mediate Lung Metastasis*
Adhesion of blood-borne cancer cells to the endothelium is a critical determinant of organ-specific metastasis. Here we show that… Expand
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Highly Cited
2001
Highly Cited
2001
Expression and biological significance of Ca2+‐activated ion channels in human keratinocytes
In whole‐cell recordings from HaCaT keratinocytes, ATP, bradykinin, and histamine caused a biphasic change of the membrane… Expand
Highly Cited
2001
Highly Cited
2001
Expression of the Ca2+-activated chloride channel genes CLCA1 and CLCA2 is downregulated in human colorectal cancer.
The role of ion channels in carcinogenesis and tumor progression remains unclear. We have used suppression subtractive… Expand
Highly Cited
1999
Highly Cited
1999
Molecular cloning and transmembrane structure of hCLCA2 from human lung, trachea, and mammary gland.
The CLCA family of Ca2+-activated Cl- channels has recently been discovered, with an increasing number of closely related members… Expand
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