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CLCA2 protein, human

Known as: Calcium-Sensitive Chloride Channel 2, hCLCA2, CaCC-3 
Calcium-activated chloride channel regulator 2 (943 aa, ~104 kDa) is encoded by the human CLCA2 gene. This protein is involved in chloride ion… 
National Institutes of Health

Related topics

Related topics

21 relations
CLCA2 geneCLCA4 geneCellular MembraneCystic Fibrosis

Broader (1)

Chloride Channels

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Loss of CLCA4 Promotes Epithelial-to-Mesenchymal Transition in Breast Cancer Cells
The epithelial to mesenchymal transition (EMT) is a developmental program in which epithelial cells downregulate their cell-cell… 
Highly Cited
2004
Highly Cited
2004
CLCA2 tumour suppressor gene in 1p31 is epigenetically regulated in breast cancer
The calcium-activated chloride channel gene family is clustered in the 1p31 region, which is frequently deleted in sporadic… 
2004
2004
Calcium-activated Chloride Channel-2 in Human Epithelia
Calcium-activated chloride channels (CLCAs) are a family of multifunctional proteins that are widely distributed in tissues. To… 
2004
2004
Re-expression of Detachment-inducible Chloride Channel mCLCA5 Suppresses Growth of Metastatic Breast Cancer Cells*
The calcium-activated chloride channel hCLCA2 has been identified as a candidate tumor suppressor in human breast cancer. It is… 
Highly Cited
2003
Highly Cited
2003
The Interacting Binding Domains of the β4 Integrin and Calcium-activated Chloride Channels (CLCAs) in Metastasis*
CLCA (chloride channel, calcium-activated) proteins are novel pulmonary vascular addresses for blood-borne, lung-metastatic… 
Highly Cited
2001
Highly Cited
2001
The Breast Cancer β4 Integrin and Endothelial Human CLCA2 Mediate Lung Metastasis*
Adhesion of blood-borne cancer cells to the endothelium is a critical determinant of organ-specific metastasis. Here we show that… 
Highly Cited
2001
Highly Cited
2001
Expression of the Ca2+-activated chloride channel genes CLCA1 and CLCA2 is downregulated in human colorectal cancer.
The role of ion channels in carcinogenesis and tumor progression remains unclear. We have used suppression subtractive… 
Highly Cited
2001
Highly Cited
2001
Expression and biological significance of Ca2+‐activated ion channels in human keratinocytes
In whole‐cell recordings from HaCaT keratinocytes, ATP, bradykinin, and histamine caused a biphasic change of the membrane… 
Review
2000
Review
2000
Molecular Characteristics And Functional Diversity Of Clca Family Members
1. In the present brief review, we describe some of the molecular and functional characteristics of a novel mammalian family of… 
Highly Cited
1999
Highly Cited
1999
Tumorigenicity of human breast cancer is associated with loss of the Ca2+-activated chloride channel CLCA2.
The human Ca2+-activated chloride channel-2 (CLCA2) is expressed in normal breast epithelium but not in breast tumors of… 
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