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CLCA2 protein, human

Known as: Calcium-Sensitive Chloride Channel 2, hCLCA2, CaCC-3 
Calcium-activated chloride channel regulator 2 (943 aa, ~104 kDa) is encoded by the human CLCA2 gene. This protein is involved in chloride ion… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Transition between epithelial and mesenchymal states is a feature of both normal development and tumor progression. We report… Expand
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2009
2009
hCLCA2 is frequently down-regulated in breast cancer and is a candidate tumor suppressor gene. We show here that the hCLCA2 gene… Expand
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Highly Cited
2004
Highly Cited
2004
To determine whether the CLCA gene family of calcium-activated chloride channels is a modulator of the basic defect of cystic… Expand
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Highly Cited
2004
Highly Cited
2004
The calcium-activated chloride channel gene family is clustered in the 1p31 region, which is frequently deleted in sporadic… Expand
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Highly Cited
2003
Highly Cited
2003
Human airway epithelia express Ca2+-activated Cl− channels (CaCC) that are activated by extracellular nucleotides (ATP and UTP… Expand
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Highly Cited
2003
Highly Cited
2003
CLCA (chloride channel, calcium-activated) proteins are novel pulmonary vascular addresses for blood-borne, lung-metastatic… Expand
Highly Cited
2001
Highly Cited
2001
Adhesion of blood-borne cancer cells to the endothelium is a critical determinant of organ-specific metastasis. Here we show that… Expand
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Highly Cited
2001
Highly Cited
2001
In whole‐cell recordings from HaCaT keratinocytes, ATP, bradykinin, and histamine caused a biphasic change of the membrane… Expand
Highly Cited
2001
Highly Cited
2001
The role of ion channels in carcinogenesis and tumor progression remains unclear. We have used suppression subtractive… Expand
Highly Cited
1999
Highly Cited
1999
The CLCA family of Ca2+-activated Cl- channels has recently been discovered, with an increasing number of closely related members… Expand
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