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CLCA2 protein, human

Known as: Calcium-Sensitive Chloride Channel 2, hCLCA2, CaCC-3 
Calcium-activated chloride channel regulator 2 (943 aa, ~104 kDa) is encoded by the human CLCA2 gene. This protein is involved in chloride ion… 
National Institutes of Health

Related topics

Related topics

21 relations
CLCA2 geneCLCA4 geneCellular MembraneCystic Fibrosis

Broader (1)

Chloride Channels

Papers overview

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2019
2019
A newly identified missense mutation in CLCA2 is associated with autosomal dominant cardiac conduction block.
2017
2017
[The effects of ERK1/2 pathway on the expression of calcium activated chloride channel in hypoxia in PASMCs rat model].
OBJECTIVE To investigate the expression of mRNA and protein of Calcium activated chloride channel (CLCA2) in hypoxic pulmonary… 
2016
2016
HUMAN CLCA2 MODULATES THE CONDUCTANCE OF CALCIUM-ACTIVATED CHLORIDE CHANNELS BY REGULATION OF INTRACELLULAR CALCIUM
2014
2014
The role of hCLCA2 and hCLCA4 in suppression of breast cancer progression
2012
2012
CLCA2 as a p53-inducible senescence mediator.
p53 is a tumor suppressor gene that is frequently mutated in multiple cancer tissues. Activated p53 protein regulates its… 
Review
2009
Review
2009
The CLCA gene family: putative therapeutic target for respiratory diseases.
The CLCA proteins were first shown to exist in bovine trachea and named as chloride channels calcium activated (CLCA) due to the… 
2008
2008
Murine mCLCA6 Is an Integral Apical Membrane Protein of Non-goblet Cell Enterocytes and Co-localizes With the Cystic Fibrosis Transmembrane Conductance Regulator
The CLCA family of proteins consists of a growing number of structurally and functionally diverse members with distinct… 
2006
2006
The Putative Chloride Channel hCLCA2 Has a Single C-terminal Transmembrane Segment*
Calcium-activated chloride channel (CLCA) proteins were first described as a family of plasma membrane Cl– channels that could be… 
2004
2004
Re-expression of Detachment-inducible Chloride Channel mCLCA5 Suppresses Growth of Metastatic Breast Cancer Cells*
The calcium-activated chloride channel hCLCA2 has been identified as a candidate tumor suppressor in human breast cancer. It is… 
Highly Cited
2003
Highly Cited
2003
The Interacting Binding Domains of the β4 Integrin and Calcium-activated Chloride Channels (CLCAs) in Metastasis*
CLCA (chloride channel, calcium-activated) proteins are novel pulmonary vascular addresses for blood-borne, lung-metastatic… 
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