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A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors
TLDR
Its localization to the 10q24 region, and rearrangements or inactivation in malignant brain tumors, suggest that LGI1 is a candidate tumor suppressor gene involved in progression of glial tumors.
The TACC domain identifies a family of centrosomal proteins that can interact with microtubules.
TLDR
The TACC domain identifies a family of centrosomal proteins that can interact with microtubules, which may explain the link between the TACC genes and cancer.
The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell
TLDR
These relationships suggest that the FGFR and TACC genes arose from a physically linked ancestral gene pair that has undergone two successive rounds of gene duplication to give rise to the three FGFR/TACC gene pairs on chromosomes 4, 8, and 10.
Expression of oligodendrocyte progenitor cell antigens by gliomas: implications for the histogenesis of brain tumors.
TLDR
Evidence is provided that glial tumors arise from glial progenitor cells that express the NG2 chondroitin sulfate proteoglycan and the alpha receptor of platelet-derived growth factor in vivo.
Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon
TLDR
The precise location of four expressed sequence tags (ESTs) within this region are reported and the cloning of a novel gene, designated TACC1 (transforming acidic coiled coil gene 1), which encodes an 8 kb transcript and which is expressed at high levels during early embryogenesis is reported.
Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade
TLDR
It is demonstrated here that monocytic (mMDSC) and granulocytic subsets of myeloid-derived suppressor cells infiltrate in the primary tumour and distant organs with different time kinetics and regulate spatiotemporal tumour plasticity.
Molecular Study of Malignant Gliomas Treated with Epidermal Growth Factor Receptor Inhibitors: Tissue Analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01
TLDR
As erlotinib and gefitinib were generally ineffective at markedly inhibiting EGFR phosphorylation in these tumors, other assays may be needed to detect molecular effects.
Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability
TLDR
This work has combined the emetine treatment with actinomycin D, which effectively prevents the upregulation of stress response genes while still stabilizing mutant transcripts, and identified mutations in the UVRAG and p300 genes.
Genetic analysis of Down syndrome-associated heart defects in mice
TLDR
The smallest critical genomic region for DS-associated heart defects is established to lay the foundation for identifying the causative gene(s) for this phenotype.
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