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CGS 21680

Known as: CGS21680 
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
The role of adenosine A2A and A2B receptors in the regulation of TNF-alpha production by human monocytes.
Highly Cited
2004
Highly Cited
2004
Striatal plasticity at the network level. Focus on adenosine A2A and D2 interactions in models of Parkinson's Disease.
Highly Cited
2004
Highly Cited
2004
Post-Ischemic Cardioprotection by A2A Adenosine Receptors: Dependent of Phosphatidylinositol 3-Kinase Pathway
Activation of myocardial A2A adenosine receptors during reperfusion has been shown to be cardioprotective. The intracellular… 
Highly Cited
2002
Highly Cited
2002
Essential Role of cAMP-response Element-binding Protein Activation by A2A Adenosine Receptors in Rescuing the Nerve Growth Factor-induced Neurite Outgrowth Impaired by Blockage of the MAPK Cascade*
We found in the present study that stimulation of the A2A adenosine receptor (A2A-R) using an A2A-selective agonist (CGS21680… 
Highly Cited
2002
Highly Cited
2002
Occupancy of adenosine A2a receptors promotes fMLP‐induced cyclic AMP accumulation in human neutrophils: impact on phospholipase D activity and recruitment of small GTPases to membranes
The aim of this study was to assess in human neutrophils theimplication of an adenosine 3′,5′‐cyclic monophosphate (cAMP… 
Highly Cited
2001
Highly Cited
2001
Adenosine A2A agonist CGS 21680 decreases the affinity of dopamine D2 receptors for dopamine in human striatum
Adenosine A2A receptors (A2AR) and dopamine D2 receptors (D2R) are highly concentrated in the striatum, where they are co… 
Highly Cited
2001
Highly Cited
2001
2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B…
Novel adenosine antagonists, 2-alkynyl-8-aryl-9-methyladenine derivatives, were synthesized as candidate hypoglycemic agents… 
Highly Cited
2001
Highly Cited
2001
Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonists.
Novel 2-propynylcyclohexyl-5'-N:-ehtylcarboxamidoadenosines, trans-substituted in the 4-position of the cyclohexyl ring, were… 
Highly Cited
1999
Highly Cited
1999
Retinal ischemic preconditioning in the rat: requirement for adenosine and repetitive induction.
PURPOSE A brief period of ischemia can induce a remarkably complete state of ischemic tolerance in the retina, a phenomenon known… 
Highly Cited
1997
Highly Cited
1997
Mutagenesis reveals structure-activity parallels between human A2A adenosine receptors and biogenic amine G protein-coupled receptors.
Structure-affinity relationships for ligand binding at the human A2A adenosine receptor have been probed using site-directed… 
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