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The capsaicin receptor: a heat-activated ion channel in the pain pathway
Capsaicin, the main pungent ingredient in ‘hot’ chilli peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to theExpand
Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors.
Sensitization of primary afferent neurons underlies much of the pain and tenderness associated with tissue injury and inflammation. The increase in excitability is caused by chemical agents releasedExpand
Modulation of TTX-R INa by PKC and PKA and Their Role in PGE2-Induced Sensitization of Rat Sensory Neurons In Vitro
A tetrodotoxin-resistant voltage-gated Na+current (TTX-R INa) appears to be the current primarily responsible for action potential generation in the cell body and terminals of nociceptive afferents.Expand
Characterization of six voltage-gated K+ currents in adult rat sensory neurons.
1. Previously three voltage-gated K+ currents were described in neurons from mammalian sensory ganglia: two transient and one sustained. Because there is considerable variability in the gatingExpand
Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia
  • J. Shin, Hawon Cho, +12 authors U. Oh
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 3 July 2002
The capsaicin-sensitive vanilloid receptor (VR1) was recently shown to play an important role in inflammatory pain (hyperalgesia), but the underlying mechanism is unknown. We hypothesized thatExpand
TRP channels: targets for the relief of pain.
Patients with inflammatory or neuropathic pain experience hypersensitivity to mechanical, thermal and/or chemical stimuli. Given the diverse etiologies and molecular mechanisms of these painExpand
Critical role of nociceptor plasticity in chronic pain
The transition from acute to chronic pain states might be the most important challenge in research to improve clinical treatment of debilitating pain. We describe a recently identified mechanism ofExpand
Epac Mediates a cAMP-to-PKC Signaling in Inflammatory Pain: An Isolectin B4(+) Neuron-Specific Mechanism
The ϵ isoform of protein kinase C (PKCϵ) has emerged as a critical second messenger in sensitization toward mechanical stimulation in models of neuropathic (diabetes, alcoholism, and cancer therapy)Expand
Signaling Pathways in Sensitization: Toward a Nociceptor Cell Biology
The electrophysiological properties of peripheral neurons activated by noxious stimuli, the primary afferent nociceptors, have been investigated intensively, and our knowledge about the molecularExpand
Pain-Induced Analgesia Mediated by Mesolimbic Reward Circuits
We tested the hypothesis that noxious stimuli induce pain modulation by activation of supraspinal structures. We found that intense noxious stimuli (i.e., subdermal injection of capsaicin or pawExpand