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The capsaicin receptor: a heat-activated ion channel in the pain pathway
- M. Caterina, M. Schumacher, M. Tominaga, Tobias A. Rosen, J. Levine, D. Julius
- 22 October 1997
The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.
Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors.
- M. Gold, D. Reichling, M. Shuster, J. Levine
- BiologyProceedings of the National Academy of Sciences…
- 6 February 1996
Modulation of TTX-R INa is a mechanism for sensitization of mammalian nociceptors, as indicated by results indicating that three agents that produce tenderness or hyperalgesia in vivo, prostaglandin E2, adenosine, and serotonin, modulate TTx-R Ina.
Modulation of TTX-R INa by PKC and PKA and Their Role in PGE2-Induced Sensitization of Rat Sensory Neurons In Vitro
Investigating the interaction between PKC and PKA revealed that although inhibitors of PKA had little effect on PKC-induced modulation of TTX-R INa, inhibitors of PKC significantly attenuated PKA- induced modulation of the current.
Characterization of six voltage-gated K+ currents in adult rat sensory neurons.
Using whole cell patch-clamp techniques, evidence is provided for the existence of six voltage-gated K+ currents in cultured dorsal root ganglion (DRG) neurons from the adult rat, and four of the six currents are differentially expressed among subpopulations of DRG neurons.
Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia
Bristolkinin, acting at B2 bradykinin receptors, excites sensory nerve endings by activating capsaicin receptors via production of 12-lipoxygenase metabolites of arachidonic acid, identifying a mechanism that might be targeted in the development of new therapeutic strategies for the treatment of inflammatory pain.
TRP channels: targets for the relief of pain.
Critical role of nociceptor plasticity in chronic pain
Signaling Pathways in Sensitization: Toward a Nociceptor Cell Biology
A Novel Nociceptor Signaling Pathway Revealed in Protein Kinase C ε Mutant Mice