• Publications
  • Influence
International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors.
Experiments with receptor antagonists and mice with targeted disruption of adenosine A(1), A(2A), and A(3) expression reveal roles for these receptors under physiological and particularly pathophysiological conditions. Expand
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
It is concluded that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation. Expand
International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update
In the 10 years since our previous International Union of Basic and Clinical Pharmacology report on the nomenclature and classification of adenosine receptors, no developments have led to majorExpand
Adenosine receptors: therapeutic aspects for inflammatory and immune diseases
This work has generated excitement regarding the potential use of adenosine-receptor-based therapies in the treatment of infection, autoimmunity, ischaemia and degenerative diseases. Expand
Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection.
  • J. Linden
  • Biology, Medicine
  • Annual review of pharmacology and toxicology
  • 2001
Novel adenosine receptor subtype-selective ligands have recently been developed that will help investigators to sort out how adenoine protects tissues from injury and to identify new therapeutic agents that hold promise for the treatment of inflammatory and ischemic diseases. Expand
A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells.
It is demonstrated that extracellular adenosine stimulates the A(2A)R to promote long-term T-cell anergy and the generation of adaptive regulatory T cells. Expand
The cardiac effects of adenosine.
Etude de mecanisme d'action de l'adenosine sur differentes cellules cardiaques et examen de son metabolisme. Discussion du role possible de l'adenosine comme mediateur des fonctions cellulairesExpand
Purinergic regulation of the immune system
How local purinergic signalling changes over time during tissue responses to injury or disease is reviewed, and the potential of targeting purInergic signalling pathways for the immunotherapeutic treatment of ischaemia, organ transplantation, autoimmunity or cancer is discussed. Expand
Cloned adenosine A3 receptors: pharmacological properties, species differences and receptor functions.
  • J. Linden
  • Biology, Medicine
  • Trends in pharmacological sciences
  • 1 August 1994
In this review, Joel Linden summarizes what is known about a new and intriguing member of the adenosine receptor family, the A3 receptor. This receptor exhibits unusually large differences inExpand
Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system
The use of purified recombinant human A2A‐ARs are used to generate a monoclonal antibody that has been used to better resolve the distribution of A3A adenosine receptors in rat brain and is consistent with the receptors' role in modulating dopaminergic neurotransmission and central control of cardiovascular function. Expand