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CGP 37849

Known as: CGP-37849 
 
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
The competitive NMDA receptor antagonists CGP 37849 and CGP 39551 are potent, orally-active anticonvulsants in rodents
SummaryAnticonvulsant properties of CGP 37849 and CGP 39551, two novel phosphono-amino acids which are competitive NMDA receptor… Expand
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Highly Cited
2000
Highly Cited
2000
Inhibition of neuronal Ca2+ influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices
Cytosolic calcium ion concentrations ([Ca2+]i) were measured in rat neocortical synaptosomes using fura‐2, and depolarization of… Expand
Highly Cited
1996
Highly Cited
1996
Behavioral stress modifies hippocampal plasticity through N-methyl-D-aspartate receptor activation.
Behavioral stress has detrimental effects on subsequent cognitive performance in many species, including humans. For example… Expand
Highly Cited
1996
Highly Cited
1996
The effects of repeated administration of diazepam, MK-801 and CGP 37849 on rat behavior in two models of anxiety
The effects of repeated administration of diazepam, MK-801 and CGP 37849 on rat behavior in the Vogel conflict test, and in the… Expand
Highly Cited
1994
Highly Cited
1994
Blockade of NMDA receptors increases cell death and birth in the developing rat dentate gyrus
Excitatory input regulates cell birth and survival in many systems. The granule cell population of the rat dentate gyrus is… Expand
Highly Cited
1994
Highly Cited
1994
Antidepressant activity of non-competitive and competitive NMDA receptor antagonists in a chronic mild stress model of depression.
The antidepressant properties of the non-competitive NMDA receptor antagonist, MK-801 (dizocilpine), and the competitive NMDA… Expand
Highly Cited
1992
Highly Cited
1992
The effect of CGP 37849 and CGP 39551, competitive NMDA receptor antagonists, in the forced swimming test.
The present study examined the effects of CGP 37849 and CGP 39551, competitive NMDA receptor antagonists, in the forced swimming… Expand
Highly Cited
1991
Highly Cited
1991
Anticonvulsant and behavioral effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and…
The orally active competitive N-methyl-D-aspartate (NMDA) receptor antagonists CGP 37849 (DL-[E]-2-amino-4-methyl-5-phosphono-3… Expand
Highly Cited
1990
Highly Cited
1990
CGP 37849 and CGP 39551: novel and potent competitive N‐methyl‐d‐aspartate receptor antagonists with oral activity
1 The pharmacological properties of CGP 37849 (dl‐(E)‐2‐amino‐4‐methyl‐5‐phosphono‐3‐pentenoic acid; 4‐methyl‐APPA) and its… Expand
1990
1990
Electrophysiological characterization of a novel potent and orally active NMDA receptor antagonist: CGP 37849 and its ethylester CGP 39551.
The selectivity and potency of the novel competitive N-methyl-D-aspartate (NMDA) receptor antagonists, CGP 37849 and CGP 39551… Expand
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