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Lack of persistent effects of ketamine in rodent models of depression
TLDR
It is indicated that ketamine neither produces enduring antidepressant-like effects in rodents nor does it display antidepressant- like behavioral or neurochemical effects after chronic treatment. Expand
Mood disorders: regulation by metabotropic glutamate receptors.
TLDR
A model is presented suggesting how the interplay of glutamate at the mGlu and at the ionotropic AMPA and NMDA receptors might account for the antidepressant-like effects of glutamatergic- and monoaminergic-based drugs affecting mood in patients. Expand
Adaptation of N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: implications for the pharmacotherapy of depression.
TLDR
It is proposed that adaptive changes in NMDA receptors may be the final common pathway for antidepressant action. Expand
New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2
TLDR
These six pathways offer new, pathophysiologically guided drug targets suggesting that novel therapies could be developed that target these six pathways simultaneously and both nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activators and glycogen synthase kinase-3 (GSK-3) inhibitors target the six above-mentioned pathways. Expand
Antidepressant-like activity of zinc: further behavioral and molecular evidence
TLDR
Data indicate a rapidly acting antidepressant-like activity of zinc in CMS and the involvement of zinc on BDNF protein and the mRNA level and in the regulation of BDNF. Expand
The involvement of NMDA and AMPA receptors in the mechanism of antidepressant-like action of zinc in the forced swim test
TLDR
Zinc administration potentiated a veratridine-evoked glutamate and aspartate release in the rat’s prefrontal cortex and hippocampus and indicates the involvement of the NMDA and AMPA glutamatergic receptors in this activity. Expand
Immobility stress induces depression-like behavior in the forced swim test in mice: effect of magnesium and imipramine.
TLDR
The present data suggest that IS-induced increase in immobility time in FST is more sensitive for detection antidepressant-like activity, however, further studies are needed to examine the effect of other antidepressants in such an experimental paradigm. Expand
Effect of zinc supplementation on antidepressant therapy in unipolar depression: a preliminary placebo-controlled study.
TLDR
This preliminary study is the first demonstration of the benefit of zinc supplementation in antidepressant therapy and the mechanism(s) may be related to modulation of glutamatergic or immune systems by zinc ion. Expand
Antidepressant activity of zinc and magnesium in view of the current hypotheses of antidepressant action.
TLDR
The available data indicate the importance of zinc and magnesium homeostasis in the psychopathology and therapy of affective disorders, and clinical studies demonstrate that the efficacy of pharmacotherapy is enhanced by supplementation with zinc andnesium. Expand
Serum zinc level in depressed patients during zinc supplementation of imipramine treatment.
TLDR
Serum zinc is a state marker of depression and a significant negative correlation was demonstrated between the Montgomery-Asberg Depression Rating Scale and the serum zinc level together with a concomitant increase in serum zinc in patients in remission. Expand
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