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D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures
The anticonvulsant activity of the novel drug D-23129 (N-(2-amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester) was evaluated in animal models of epileptic seizures. D-23129 was activeExpand
Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats.
The novel anticonvulsant drug ucb L059 ((S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide) was evaluated in several rodent models of partial and generalized seizures. Ucb L059 (27-108 mg/kg i.p.)Expand
The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models
Although seizure models using systemic administration of the chemoconvulsant pentylenetetrazol (PTZ) for induction of generalized clonic seizures in rodents are widely employed to identify potentialExpand
Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy.
We have previously shown that the novel anticonvulsant levetiracetam exerts potent anticonvulsant activity against both focal and secondarily generalized seizures in fully amygdala-kindled rats, i.e.Expand
The behavioural effects of MK-801 in rats: involvement of dopaminergic, serotonergic and noradrenergic systems.
The non-competitive NMDA receptor antagonist, MK-801 (dizocilpine), induces in rats a characteristic behavioural syndrome with ataxia, stereotypies and hyperlocomotion. At least part of thisExpand
Sex differences in NMDA receptor mediated responses in rats.
The behavioural effects of the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 (dizocilpine) were compared in age-matched female and male Wistar rats. At a dose of 0.1 mg/kg i.p., almost noExpand
The sz mutant hamster: A genetic model of epilepsy or of paroxysmal dystonia?
Attacks of sustained dystonic postures of limbs and trunk can be initiated by mild environmental stimuli in an inbred line of Syrian hamsters. The trait is determined by an autosomal simple recessiveExpand
Use of Inhibitors of γ‐Aminobutyric Acid (GABA) Transaminase for the Estimation of GABA Turnover in Various Brain Regions of Rats: A Reevaluation of Aminooxyacetic Acid
Abstract: The technique of estimating γ‐aminobutyric acid (GABA) turnover by inhibiting its major degrading enzyme GABA‐T (4‐aminobutyrate:2‐oxoglutarate aminotransferase; EC and measuringExpand
Amygdala-kindling as a model for chronic efficacy studies on antiepileptic drugs: Experiments with carbamazepine
The anticonvulsant properties of carbamazepine were evaluated after single and multiple doses in the kindled amygdaloid seizure model in rats. Carbamazepine significantly reduced severity andExpand
Anticonvulsant and behavioral effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and
The orally active competitive N-methyl-D-aspartate (NMDA) receptor antagonists CGP 37849 (DL-[E]-2-amino-4-methyl-5-phosphono-3-pentenoic acid) and its ethyl ester CGP 39551 were evaluated inExpand