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CDT1 Gene

Known as: RIS2, CDT1, DNA Replication Factor Gene 
This gene is involved in pre-initiation of DNA replication.
National Institutes of Health

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CDT1 wt Allele
DNA ReplicationDNA Replication FactorReplication InitiationReplication Licensing

Papers overview

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Highly Cited
2012
Highly Cited
2012
Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor.
Radiotherapy is used in locally advanced pancreatic cancers in which it can improve survival in combination with gemcitabine… 
Highly Cited
2011
Highly Cited
2011
Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover.
Loss of NEDD8-activating enzyme (NAE) function by siRNA knockdown or inhibition by the small molecule NAE inhibitor MLN4924 leads… 
Highly Cited
2009
Highly Cited
2009
DNA replication licensing and progenitor numbers are increased by progesterone in normal human breast.
Proliferation in the nonpregnant human breast is highest in the luteal phase of the menstrual cycle when serum progesterone… 
Highly Cited
2005
Highly Cited
2005
Degradation of Cdt1 during S Phase Is Skp2-independent and Is Required for Efficient Progression of Mammalian Cells through S Phase*
Previous reports have shown that the N terminus of Cdt1 is required for its degradation during S phase (Li, X., Zhao, Q., Liao, R… 
Highly Cited
2004
Highly Cited
2004
Targeted ubiquitination of CDT1 by the DDB1–CUL4A–ROC1 ligase in response to DNA damage
Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse… 
Highly Cited
2004
Highly Cited
2004
Cyclin-dependent Kinases Phosphorylate Human Cdt1 and Induce Its Degradation*
Eukaryotic cells tightly control DNA replication so that replication origins fire only once during S phase within the same cell… 
Highly Cited
2004
Highly Cited
2004
Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines.
Licensing origins for replication upon completion of mitosis ensures genomic stability in cycling cells. Cdt1 was recently… 
Highly Cited
2003
Highly Cited
2003
Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint
Genomic integrity is maintained by checkpoints that guard against undesired replication after DNA damage. Here, we show that CDT1… 
Highly Cited
2002
Highly Cited
2002
Identification of Tah11/Sid2 as the Ortholog of the Replication Licensing Factor Cdt1 in Saccharomyces cerevisiae
Highly Cited
2001
Highly Cited
2001
Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication
Cdc18/Cdc6 and Cdt1 are essential initiation factors for DNA replication. In this paper we show that expression of Cdc18 in… 
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