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CDT1 Gene

Known as: RIS2, CDT1, DNA Replication Factor Gene 
This gene is involved in pre-initiation of DNA replication.
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Loss of NEDD8-activating enzyme (NAE) function by siRNA knockdown or inhibition by the small molecule NAE inhibitor MLN4924 leads… Expand
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Highly Cited
2006
Highly Cited
2006
Checkpoint genes maintain genomic stability by arresting cells after DNA damage. Many of these genes also control cell cycle… Expand
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Highly Cited
2005
Highly Cited
2005
Previous reports have shown that the N terminus of Cdt1 is required for its degradation during S phase (Li, X., Zhao, Q., Liao, R… Expand
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Highly Cited
2004
Highly Cited
2004
Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse… Expand
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Highly Cited
2004
Highly Cited
2004
Eukaryotic cells tightly control DNA replication so that replication origins fire only once during S phase within the same cell… Expand
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Highly Cited
2004
Highly Cited
2004
Geminin is an unstable inhibitor of DNA replication that negatively regulates the licensing factor CDT1 and inhibits pre… Expand
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Highly Cited
2004
Highly Cited
2004
Chromosomal DNA replication requires the recruitment of the six-subunit minichromosome maintenance (Mcm) complex to chromatin… Expand
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Highly Cited
2003
Highly Cited
2003
Genomic integrity is maintained by checkpoints that guard against undesired replication after DNA damage. Here, we show that CDT1… Expand
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Highly Cited
2002
Highly Cited
2002
The expression of a gene, designated as Retroviral insertion site (Ris)2, was activated by retroviral DNA integration in an… Expand
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2002
2002
Faithful duplication of the genetic material requires that replication origins fire only once per cell cycle. Central to this… Expand
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