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CDT1 Gene

Known as: RIS2, CDT1, DNA Replication Factor Gene 
This gene is involved in pre-initiation of DNA replication.
National Institutes of Health

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CDT1 wt Allele
DNA ReplicationDNA Replication FactorReplication InitiationReplication Licensing

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
POSSIBLE NATURE OF THE RADIATION-INDUCED SIGNAL IN NAILS: HIGH-FIELD EPR, CONFIRMING CHEMICAL SYNTHESIS, AND QUANTUM CHEMICAL CALCULATIONS.
Exposure of finger- and toe-nails to ionizing radiation generates an Electron Paramagnetic Resonance (EPR) signal whose intensity… 
2014
2014
CDK1-dependent Inhibition of the E3 Ubiquitin Ligase CRL4CDT2 Ensures Robust Transition from S Phase to Mitosis*
Background: CRL4CDT2 mediates replication-coupled destruction during S phase. CRL4CDT2 substrates reaccumulate by an unexplored… 
2012
2012
Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos
Cdt1 plays a key role in licensing DNA for replication. In the somatic cells of metazoans, both Cdt1 and its natural inhibitor… 
Highly Cited
2010
Highly Cited
2010
Jnk2 Effects on Tumor Development, Genetic Instability and Replicative Stress in an Oncogene-Driven Mouse Mammary Tumor Model
Oncogenes induce cell proliferation leading to replicative stress, DNA damage and genomic instability. A wide variety of cellular… 
Highly Cited
2006
Highly Cited
2006
Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability
The activity of human Cdt1 is negatively regulated by multiple mechanisms. This suggests that Cdt1 deregulation may have a… 
Review
2005
Review
2005
Geminin-Cdt1 balance is critical for genetic stability.
2005
2005
Caenorhabditis elegans Geminin Homologue Participates in Cell Cycle Regulation and Germ Line Development*
Cdt1 is an essential component for the assembly of a pre-replicative complex. Cdt1 activity is inhibited by geminin, which also… 
2005
2005
Levels of the origin-binding protein Double parked and its inhibitor Geminin increase in response to replication stress
The regulation of a pre-replicative complex (pre-RC) at origins ensures that the genome is replicated only once per cell cycle… 
Highly Cited
2004
Highly Cited
2004
Genome based identification and analysis of the pre‐replicative complex of Arabidopsis thaliana
Highly Cited
2001
Highly Cited
2001
Redundant control of rereplication in fission yeast
The initiation of DNA replication at replication origins in eukaryotic cells is tightly controlled to ensure that the genome is… 
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