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Replication Licensing

A process that limits duplication of the genome to once per cell division cycle. In eukaryotes replication origins are limited to a single initiation… Expand
National Institutes of Health

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Highly Cited
2016
Highly Cited
2016
The cyclin-dependent kinase inhibitor p21WAF1/CIP1 (p21) is a cell-cycle checkpoint effector and inducer of senescence, regulated… Expand
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Highly Cited
2010
Highly Cited
2010
HBO1, an H4-specific histone acetylase, is a coactivator of the DNA replication licensing factor Cdt1. HBO1 acetylase activity is… Expand
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Highly Cited
2008
Highly Cited
2008
The faithful replication of genomic DNA is crucial for maintaining genome stability. In eukaryotes, DNA rereplication is… Expand
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Review
2008
Review
2008
Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division… Expand
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Highly Cited
2006
Highly Cited
2006
The initiation of DNA replication is tightly regulated in eukaryotic cells to ensure that the genome is precisely duplicated once… Expand
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Review
2005
Review
2005
To ensure its duplication, chromosomal DNA must be precisely duplicated in each cell cycle, with no sections left unreplicated… Expand
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Highly Cited
2003
Highly Cited
2003
To maintain genome stability, DNA replication is strictly regulated to occur only once per cell cycle. In eukaryotes, the… Expand
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Review
2002
Review
2002
The proliferation of eukaryotic cells is a highly regulated process that depends on the precise duplication of chromosomal DNA in… Expand
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Highly Cited
2002
Highly Cited
2002
Replication origins are ‘licensed' for a single initiation event by loading Mcm2-7 complexes during late mitosis and G1… Expand
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Highly Cited
2001
Highly Cited
2001
The convergence point of growth regulatory pathways that control cell proliferation is the initiation of genome replication, the… Expand
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