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Replication Licensing

A process that limits duplication of the genome to once per cell division cycle. In eukaryotes replication origins are limited to a single initiation… 
National Institutes of Health

Related topics

Related topics

22 relations
CDC6 protein, humanCDT1 GeneCDT1 wt AlleleDNA Replication

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication Licensing*
Background: Idas is a homologue of the proliferation and differentiation regulator, Geminin. Results: Idas and Geminin form… 
2010
2010
Activation of Cdk2/Cyclin E complexes is dependent on the origin of replication licensing factor Cdc6 in mammalian cells
Cyclin E-associated CDK2 activity is required for the initiation of DNA synthesis in human cells. CDK2 activity is tightly… 
2009
2009
Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells
When human cells enter S-phase, overlapping differential inhibitory mechanisms downregulate the replication licensing factors… 
2007
2007
A novel quantitative proteomics strategy to study phosphorylation-dependent peptide-protein interactions.
Phosphorylation-dependent protein-protein interactions provide the mechanism for a large number of intracellular signal… 
2004
2004
The regulation of competence to replicate in meiosis by Cdc6 is conserved during evolution
DNA replication licensing is an important step in the cell cycle at which cells become competent for DNA replication. When the… 
Highly Cited
2002
Highly Cited
2002
Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma.
The MYCN oncogene is amplified in approximately 25% of neuroblastoma tumors and is the most significant negative prognostic… 
Review
1997
Review
1997
The DNA replication licensing system.
The Xenopus cell free system has proved a good model system to study in vitro DNA replication and the mechanism preventing… 
Review
1996
Review
1996
Cell cycle control of replication initiation in eukaryotes.
Review
1996
Review
1996
Coordinating DNA replication with cell division: current status of the licensing concept.
The replication of the genetic material during cell doubling is regulated at three apparently distinct levels. In the eukaryote… 
1995
1995
A murine replication protein accumulates temporarily in the heterochromatic regions of nuclei prior to initiation of DNA replication.
We have analyzed the expression of the murine P1 gene, the mammalian homologue of the yeast MCM3 protein, during the mitotic cell… 
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