Replication Licensing

A process that limits duplication of the genome to once per cell division cycle. In eukaryotes replication origins are limited to a single initiation… (More)

Topic mentions per year

Topic mentions per year

1993-2017
02419932017

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2013
2013
Geminin is an important regulator of proliferation and differentiation in metazoans, which predominantly inhibits the DNA… (More)
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2009
2009
Replication of eukaryotic genomes is limited to once per cell cycle, by a two-step mechanism. DNA replication origins are first… (More)
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Highly Cited
2007
Highly Cited
2007
Xenopus egg extract supports all the major cell-cycle transitions in vitro. We have used a proteomics approach to identify… (More)
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2007
2007
All eukaryotes use multiple controls to restrict DNA replication to once per cell cycle. Nevertheless, inactivation of a single… (More)
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Highly Cited
2006
Highly Cited
2006
Correct regulation of the replication licensing system ensures that no DNA is rereplicated in a single cell cycle. When the… (More)
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Highly Cited
2004
Highly Cited
2004
The cohesin complex is a central player in sister chromatid cohesion, a process that ensures the faithful segregation of… (More)
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2002
2002
Faithful duplication of the genetic material requires that replication origins fire only once per cell cycle. Central to this… (More)
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1997
1997
The replication licensing factor (RLF) is an essential initiation factor that is involved in preventing re-replication of… (More)
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Highly Cited
1996
Highly Cited
1996
The origin recognition complex (ORC) binds to origins of replication in budding yeast. We have cloned a Xenopus homolog of the… (More)
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Highly Cited
1993
Highly Cited
1993
Xenopus egg extracts treated with the protein kinase inhibitor 6-dimethylaminopurine (6-DMAP) are unable to support the… (More)
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