Skip to search formSkip to main contentSkip to account menu

CDK1 gene

Known as: Cyclin-Dependent Kinase 1 Gene, p34(CDC2), CELL CYCLE CONTROLLER CDC2 
This gene is involved in the cellular transition from the G1/S phase and from the G2/M phase of the cell cycle.
National Institutes of Health

Related topics

Related topics

6 relations
CDC2 Protein KinaseCDK1 wt AlleleCell Cycle ControlPhosphorylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Engaging Anaphase Catastrophe Mechanisms to Eradicate Aneuploid Cancers
Cancer cells often have supernumerary centrosomes that promote genomic instability, a pathognomonic feature of cancer. During… 
2017
2017
Long non-coding RNA colon cancer–associated transcript 1 functions as a competing endogenous RNA to regulate cyclin-dependent kinase 1 expression by sponging miR-490-3p in hepatocellular carcinoma…
Hepatocellular carcinoma is an aggressive neoplasm and is one of the most common human cancers. Recently, long non-coding RNAs… 
2013
2013
Ser 15 of WEE1B is a potential PKA phosphorylation target in G2/M transition in one-cell stage mouse embryos.
The WEE1 kinase family has been shown to be the major kinase family responsible for phosphorylating Tyr 15 on cyclin-dependent… 
Highly Cited
2011
Highly Cited
2011
Mitotic Modulation of Translation Elongation Factor 1 Leads to Hindered tRNA Delivery to Ribosomes*
Translation elongation in eukaryotes is mediated by the concerted actions of elongation factor 1A (eEF1A), which delivers… 
2011
2011
DNA Damage Response Is Suppressed by the High Cyclin-dependent Kinase 1 Activity in Mitotic Mammalian Cells*
DNA damage response (DDR) is vital for genomic stability, and its deficiency is linked to tumorigenesis. Extensive studies in… 
2010
2010
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase
Defining the links between cell division and DNA replication is essential for understanding normal cell cycle progression and… 
2007
2007
p53 Regulates Cellular Responses to Environmental Carcinogen Benzo[a]pyrene-7,8-diol-9,10-epoxide in Human Lung Cancer Cells
The p53 tumor suppressor is a mutational target of environmental carcinogen anti-benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE). We… 
Highly Cited
2006
Highly Cited
2006
Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin‐dependent kinase 1 (Cdk1)
Chk1 is phosphorylated at Ser317 and Ser345 by ATR in response to stalled replication and genotoxic stresses. This Chk1… 
Highly Cited
2006
Highly Cited
2006
Essential CDK1-inhibitory role for separase during meiosis I in vertebrate oocytes
Separase not only triggers anaphase of meiosis I by proteolytic cleavage of cohesin on chromosome arms, but in vitro vertebrate… 
Highly Cited
2004
Highly Cited
2004
Inhibition of Rat Mammary Gland Carcinogenesis by Simultaneous Targeting of Cyclooxygenase-2 and Peroxisome Proliferator-activated Receptor γ
We examined the effect of celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, and N-(9-fluorenyl-methyloxycarbonyl)-l-leucine (F-l… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)