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CDK1 wt Allele

Known as: P34CDC2, p34 Protein Kinase Gene, Cell Division Cycle 2 Protein Gene 
Human CDK1 wild-type allele is located in the vicinity of 10q21.1 and is approximately 61 kb in length. This allele, which encodes cyclin-dependent… 
National Institutes of Health

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10q21.1CDC25 and CHK1 Regulatory PathwayCDK1 geneCell Cycle

Papers overview

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2005
2005
Relationship between intracellular localization of p34cdc2 protein and differentiation of esophageal squamous cell carcinoma
PurposeG2/M cyclins including cyclins A and B can exert their biologic functions of mitosis and proliferation of the tumor cells… 
2003
2003
Cdc2 expression in primary thyroid lymphoma: its relationship with biological aggressiveness and G2 cyclins.
Previous studies have demonstrated that the G2-M modulators contribute to the progression of human neoplasms. In this study, we… 
1998
1998
p34cdc2 in invasive breast cancer: relationship to DNA content, Ki67 index and c‐erbB‐2 expression
Aims: One‐hundred and eighty‐eight cases of human mammary carcinoma were examined immunohistochemically for their expression of… 
1998
1998
Modulation of aflatoxin-B1 hepatocarcinogenesis in trout by dehydroepiandrosterone: initiation/post-initiation and latency effects.
Previously, we demonstrated that dehydroepiandrosterone (DHEA) enhances aflatoxin B1 (AFB1) hepatocarcinogenesis in trout when… 
1998
1998
Induction of p34cdc2 in mouse parotid glands upon activation of beta1-adrenergic receptors.
Dramatic morphological, biochemical and cytological changes occur in parotid glands of rats and mice which have been treated with… 
1998
1998
Cisplatin-induced inhibition of p34cdc2 is abolished by 5-fluorouracil.
Clinical (Dimery and Hong, J Nat Cancer Inst 1993; 85: 95- 111) and experimental studies (Scanlon et al., Proc Natl Acad Sci USA… 
1996
1996
Increased p34cdc2-dependent kinase activity during apoptosis: a possible activation mechanism of DNase I leading to DNA breakdown.
Cells undergoing apoptosis typically exhibit distinctive morphological characteristics. Early events include the rounding up of… 
1995
1995
Over‐expression and amplification of the CDC2 gene in leukaemia cells
The expression and structure of the cdc2 gene, one of the master regulators of the eukaryotic cell cycle, were investigated in… 
1995
1995
Dissociation of p34cdc2 complex formation from phosphorylation and histone H1 kinase activity.
The cell cycle inhibitor mimosine was used to examine the activation of the p34cdc2 protein kinase in S phase of the cell cycle… 
1991
1991
p34cdc2 is physically associated with and phosphorylated by a cdc2-specific tyrosine kinase.
The mammalian homologue of the yeast cdc2 gene encodes a 34-kilodalton serine/threonine kinase that is a subunit of M phase… 
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