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CDK1 wt Allele

Known as: P34CDC2, p34 Protein Kinase Gene, Cell Division Cycle 2 Protein Gene 
Human CDK1 wild-type allele is located in the vicinity of 10q21.1 and is approximately 61 kb in length. This allele, which encodes cyclin-dependent… 
National Institutes of Health

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Related topics

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10q21.1CDC25 and CHK1 Regulatory PathwayCDK1 geneCell Cycle

Papers overview

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Highly Cited
2008
Highly Cited
2008
cdc2–cyclin B regulates eEF2 kinase activity in a cell cycle‐ and amino acid‐dependent manner
The calcium/calmodulin‐dependent kinase that phosphorylates and inactivates eukaryotic elongation factor 2 (eEF2 kinase; eEF2K… 
Highly Cited
2000
Highly Cited
2000
The Disappearance of Cyclins A and B and the Increase in Activity of the G2/M-Phase Cellular Kinase cdc2 in Herpes Simplex Virus 1-Infected Cells Require Expression of the α22/US1.5 and UL13 Viral…
ABSTRACT In uninfected cells the G2/M transition is regulated by cyclin kinase complex containing cdc2 and, initially, cyclin A… 
Highly Cited
1997
Highly Cited
1997
Construction by gene targeting in human cells of a ‘conditional’ CDC2 mutant that rereplicates its DNA
We describe a novel gene targeting strategy for the genetic analysis of essential genes in mammalian cells and its use to study… 
Highly Cited
1996
Highly Cited
1996
Selective radiosensitization of p53–deficient cells by caffeine–mediated activation of p34cdc2 kinase
The induction of tumor cell death by anticancer therapy results from a genetic program of autonomous cell death termed apoptosis… 
Highly Cited
1992
Highly Cited
1992
Role of phosphorylation in p34cdc2 activation: identification of an activating kinase.
Phosphorylation of p34cdc2 can both positively and negatively regulate its kinase activity. We have mapped two phosphorylation… 
Highly Cited
1992
Highly Cited
1992
Relocation and distinct subcellular localization of p34cdc2‐cyclin B complex at meiosis reinitiation in starfish oocytes.
M phase promoting factor (MPF) is a major element controlling entry into the M phase of the eukaryotic cell cycle. MPF is… 
Highly Cited
1991
Highly Cited
1991
Activation of p34cdc2 protein kinase activity in meiotic and mitotic cell cycles in mouse oocytes and embryos.
p34cdc2 protein kinase is a universal regulator of M-phase in eukaryotic cell cycle. To investigate the regulation of meiotic and… 
Highly Cited
1991
Highly Cited
1991
Cyclin B targets p34cdc2 for tyrosine phosphorylation.
A universal intracellular factor, the ‘M phase‐promoting factor’ (MPF), triggers the G2/M transition of the cell cycle in all… 
Review
1990
Review
1990
p34cdc2: the S and M kinase?
In the yeast cell cycle, the induction of two very different processes, DNA synthesis (S-phase) and mitosis (M-phase), requires… 
Highly Cited
1987
Highly Cited
1987
p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase.
cdc2+ encodes a protein kinase that is required during both G1 and G2 phases of the cell division cycle in fission yeast. suc1… 
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