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We describe a novel gene targeting strategy for the genetic analysis of essential genes in mammalian cells and its use to study… Expand The induction of tumor cell death by anticancer therapy results from a genetic program of autonomous cell death termed apoptosis… Expand During their development, mammalian oocytes acquire the ability to resume meiosis. We demonstrate that the concentration of… Expand Phosphorylation of p34cdc2 can both positively and negatively regulate its kinase activity. We have mapped two phosphorylation… Expand M phase promoting factor (MPF) is a major element controlling entry into the M phase of the eukaryotic cell cycle. MPF is… Expand Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it… Expand p34cdc2 protein kinase is a universal regulator of M-phase in eukaryotic cell cycle. To investigate the regulation of meiotic and… Expand In the yeast cell cycle, the induction of two very different processes, DNA synthesis (S-phase) and mitosis (M-phase), requires… Expand The cdc2+ gene product p34cdc2 is located immunocytochemically in both the nucleus and cytoplasm of human cells. It is uniformly… Expand cdc2+ encodes a protein kinase that is required during both G1 and G2 phases of the cell division cycle in fission yeast. suc1… Expand