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CDK1 wt Allele

Known as: P34CDC2, p34 Protein Kinase Gene, Cell Division Cycle 2 Protein Gene 
Human CDK1 wild-type allele is located in the vicinity of 10q21.1 and is approximately 61 kb in length. This allele, which encodes cyclin-dependent… Expand
National Institutes of Health

Papers overview

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Highly Cited
1997
Highly Cited
1997
We describe a novel gene targeting strategy for the genetic analysis of essential genes in mammalian cells and its use to study… Expand
Highly Cited
1996
Highly Cited
1996
The induction of tumor cell death by anticancer therapy results from a genetic program of autonomous cell death termed apoptosis… Expand
Highly Cited
1996
Highly Cited
1996
During their development, mammalian oocytes acquire the ability to resume meiosis. We demonstrate that the concentration of… Expand
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Highly Cited
1992
Highly Cited
1992
Phosphorylation of p34cdc2 can both positively and negatively regulate its kinase activity. We have mapped two phosphorylation… Expand
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Highly Cited
1992
Highly Cited
1992
M phase promoting factor (MPF) is a major element controlling entry into the M phase of the eukaryotic cell cycle. MPF is… Expand
Highly Cited
1991
Highly Cited
1991
Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it… Expand
Highly Cited
1991
Highly Cited
1991
p34cdc2 protein kinase is a universal regulator of M-phase in eukaryotic cell cycle. To investigate the regulation of meiotic and… Expand
Review
1990
Review
1990
In the yeast cell cycle, the induction of two very different processes, DNA synthesis (S-phase) and mitosis (M-phase), requires… Expand
Highly Cited
1989
Highly Cited
1989
The cdc2+ gene product p34cdc2 is located immunocytochemically in both the nucleus and cytoplasm of human cells. It is uniformly… Expand
Highly Cited
1987
Highly Cited
1987
cdc2+ encodes a protein kinase that is required during both G1 and G2 phases of the cell division cycle in fission yeast. suc1… Expand