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Strategies to improve radiotherapy with targeted drugs
Radiotherapy is used to treat approximately 50% of all cancer patients, with varying success. The dose of ionizing radiation that can be given to the tumour is determined by the sensitivity of theExpand
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Hypoxia in head and neck cancer: How much, how important?
Hypoxia develops in tumors because of a less ordered, often chaotic, and leaky vascular supply compared with that in normal tissues. In preclinical models, hypoxia has been shown to be associatedExpand
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A method to measure the duration of DNA synthesis and the potential doubling time from a single sample.
A method is described whereby the DNA synthesis time, Ts, can be calculated using data of a single sample of cells taken several hours after labelling with bromodeoxyuridine (BrdUrd). The methodExpand
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Accelerated fractionation (AF) compared to conventional fractionation (CF) improves loco-regional control in the radiotherapy of advanced head and neck cancers: results of the EORTC 22851 randomized
Abstract Background and purpose : A 5 week-hyperfractionated and accelerated radiotherapy regimen without reduction of the total dose was developed to fight tumour repopulation during treatment andExpand
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Intraperitoneal cisplatin with regional hyperthermia in advanced ovarian cancer: pharmacokinetics and cisplatin-DNA adduct formation in patients and ovarian cancer cell lines.
The purpose of this study was to investigate the influence of hyperthermia on cisplatin pharmacokinetics and DNA adduct formation. The latter was investigated both in tumour cell lines in vitro andExpand
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Accelerated fractionation (AF) compared to conventional fractionation (CF) improves loco-regional control in the radiotherapy of advanced head and neck cancers: results of the EORTC 22851 randomized
BACKGROUND AND PURPOSE A 5 week-hyperfractionated and accelerated radiotherapy regimen without reduction of the total dose was developed to fight tumour repopulation during treatment and tumourExpand
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Predicting outcomes in radiation oncology—multifactorial decision support systems
With the emergence of individualized medicine and the increasing amount and complexity of available medical data, a growing need exists for the development of clinical decision-support systems basedExpand
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A gene expression model of intrinsic tumor radiosensitivity: prediction of response and prognosis after chemoradiation.
PURPOSE Development of a radiosensitivity predictive assay is a central goal of radiation oncology. We reasoned a gene expression model could be developed to predict intrinsic radiosensitivity andExpand
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DNA‐adduct levels as a predictor of outcome for NSCLC patients receiving daily cisplatin and radiotherapy
We aimed to investigate whether biological factors related to radiosensitivity and chemosensitivity have prognostic significance in non‐small‐cell‐lung‐cancer (NSCLC) patients treated with daily lowExpand
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Resistance of hypoxic cells to ionizing radiation is influenced by homologous recombination status.
PURPOSE To determine the role of DNA repair in hypoxic radioresistance. METHODS AND MATERIALS Chinese hamster cell lines with mutations in homologous recombination (XRCC2, XRCC3, BRAC2, RAD51C) orExpand
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