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Impaired Control of IRES-Mediated Translation in X-Linked Dyskeratosis Congenita
The DKC1 gene encodes a pseudouridine synthase that modifies ribosomal RNA (rRNA). DKC1 is mutated in people with X-linked dyskeratosis congenita (X-DC), a disease characterized by bone marrow… Expand
Monoubiquitination of H2AX Protein Regulates DNA Damage Response Signaling
- Mei-Ren Pan, G. Peng, W. Hung, Shiaw-Yih Lin
- Biology, Medicine
- The Journal of Biological Chemistry
- 15 June 2011
Double strand breaks (DSBs) are the most deleterious of the DNA lesions that initiate genomic instability and promote tumorigenesis. Cells have evolved a complex protein network to detect, signal,… Expand
Rak functions as a tumor suppressor by regulating PTEN protein stability and function.
Expression of the PTEN tumor suppressor is frequently lost in breast cancer in the absence of mutation or promoter methylation through as yet undetermined mechanisms. In this study, we demonstrate… Expand
A Strategy for the Proliferation of Ulva prolifera, Main Causative Species of Green Tides, with Formation of Sporangia by Fragmentation
Ulva prolifera, a common green seaweed, is one of the causative species of green tides that occurred frequently along the shores of Qingdao in 2008 and had detrimental effects on the preparations for… Expand
ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade
ARID1A (the AT-rich interaction domain 1A, also known as BAF250a) is one of the most commonly mutated genes in cancer1,2. The majority of ARID1A mutations are inactivating mutations and lead to loss… Expand
Genome-wide Transcriptome Profiling of Homologous Recombination DNA Repair
Homologous recombination (HR) repair deficiency predisposes to cancer development, but also sensitizes cancer cells to DNA-damage-inducing therapeutics. Here we identify an HR-defect (HRD) gene… Expand
Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway.
The maintenance of genome integrity is essential for the proper function and survival of all organisms. Human cells have evolved prompt and efficient DNA damage response to eliminate the detrimental… Expand
Evaluation of the ArcCHECK QA system for IMRT and VMAT verification.
- Guangjun Li, Yingjie Zhang, +4 authors Q. Jiang
- Mathematics, Medicine
- Physica medica : PM : an international journal…
- 1 May 2013
The purposes of this study were to perform tests for the ArcCHECK QA system, and to evaluate the suitability of this system for IMRT and VMAT verification. The device was tested for short term… Expand
ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors.
UNLABELLED ARID1A, SWI/SNF chromatin remodeling complex subunit, is a recently identified tumor suppressor that is mutated in a broad spectrum of human cancers. Thus, it is of fundamental clinical… Expand
BRIT1/MCPH1 Links Chromatin Remodeling to DNA Damage Response
To detect and repair damaged DNA, DNA-damage-response proteins need to overcome the barrier of condensed chromatin to gain access to DNA lesions. ATP-dependent chromatin remodelling is one of the… Expand