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CDC5L gene

Known as: CEF1, CDC5-LIKE, PCDC5RP 
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
Structure of a spliceosome remodelled for exon ligation
The spliceosome excises introns from pre-mRNAs in two sequential transesterifications—branching and exon ligation—catalysed at a… 
Highly Cited
2004
Highly Cited
2004
A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing
During catalytic activation of the spliceosome, snRNP remodeling events occur, leading to the formation of a 35S U5 snRNP that… 
Highly Cited
2003
Highly Cited
2003
Polo-like kinase Cdc5 promotes chiasmata formation and cosegregation of sister centromeres at meiosis I
During meiosis, two rounds of chromosome segregation occur after a single round of DNA replication, producing haploid progeny… 
Highly Cited
2003
Highly Cited
2003
Role of Polo-like Kinase CDC5 in Programming Meiosis I Chromosome Segregation
Meiosis is a specialized cell division in which two chromosome segregation phases follow a single DNA replication phase. The… 
Highly Cited
2003
Highly Cited
2003
The role of the polo kinase Cdc5 in controlling Cdc14 localization.
In budding yeast, the protein phosphatase Cdc14 controls exit from mitosis. Its activity is regulated by a competitive inhibitor… 
Highly Cited
2000
Highly Cited
2000
Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry
Recently, we identified proteins that co‐purify with the human spliceosome using mass spectrometry. One of the identified… 
Highly Cited
2000
Highly Cited
2000
Essential Function of the Polo Box of Cdc5 in Subcellular Localization and Induction of Cytokinetic Structures
ABSTRACT Members of the polo subfamily of protein kinases play pivotal roles in cell proliferation. In addition to the kinase… 
Highly Cited
1997
Highly Cited
1997
Plk is a functional homolog of Saccharomyces cerevisiae Cdc5, and elevated Plk activity induces multiple septation structures
Plk is a mammalian serine/threonine protein kinase whose activity peaks at the onset of M phase. It is closely related to other… 
Highly Cited
1993
Highly Cited
1993
A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5
We have isolated a multicopy suppressor of the temperature-sensitive growth phenotype of organisms carrying mutations of DBF4, a… 
Highly Cited
1993
Highly Cited
1993
A conserved mitotic kinase active at late anaphase—telophase in syncytial Drosophila embryos
MUTATIONS in the Drosophila gene polo cause abnormal mitotic and meiotic divisions1,2. This gene encodes a 577-amino-acid protein… 
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