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Nuclear speckles: a model for nuclear organelles
Speckles are subnuclear structures that are enriched in pre-messenger RNA splicing factors and are located in the interchromatin regions of the nucleoplasm of mammalian cells, and can cycle continuously between speckles and other nuclear locations, including active transcription sites. Expand
The multifunctional nucleolus
Although the nucleolus is primarily associated with ribosome biogenesis, several lines of evidence now show that it has additional functions, such as regulation of mitosis, cell-cycle progression and proliferation, many forms of stress response and biogenesis of multiple ribonucleoprotein particles. Expand
The Nucleolus under Stress
Nucleolar function in the stress-induced regulation of p53 and the specific changes in nucleolar morphology and composition that occur upon stress are reviewed. Expand
Nucleolar proteome dynamics
The data establish a quantitative proteomic approach for the temporal characterization of protein flux through cellular organelles and demonstrate that the nucleolar proteome changes significantly over time in response to changes in cellular growth conditions. Expand
Paraspeckles A Novel Nuclear Domain
It is shown that PSP1 accumulates in a new nucleoplasmic compartment, termed paraspeckles, that also contains at least two other protein components: PSP2 and p54/nrb. Expand
Proteomic analysis of the Arabidopsis nucleolus suggests novel nucleolar functions.
The first proteomic analysis of plant (Arabidopsis thaliana) nucleoli is described, in which 217 proteins are identified, allowing a direct comparison of the proteomes of an important nuclear structure between two widely divergent species: human and Arabidopsis. Expand
Cajal bodies: a long history of discovery.
  • M. Cioce, A. Lamond
  • Biology, Medicine
  • Annual review of cell and developmental biology
  • 7 October 2005
This review surveys what is known about the structure and function of the subnuclear domains called Cajal bodies, and considers the interesting links that have emerged between CBs and alterations in nuclear structure apparent in a range of human pathologies. Expand
Large-scale proteomic analysis of the human spliceosome.
This investigation provides the most detailed inventory of human spliceosome-associated factors to date, and the data indicate a number of interesting links coordinating splicing with other steps in the gene expression pathway. Expand
Directed Proteomic Analysis of the Human Nucleolus
This extensive proteomic analysis of human nucleoli shows that nucleoli have a surprisingly large protein complexity and supports the view that the nucleolus may perform additional functions beyond its known role in ribosome subunit biogenesis. Expand
Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells
It is shown that PML is specifically localized within a discrete subnuclear compartment corresponding to nuclear bodies recognized by patient autoimmune sera and proposed that the beneficial role of RA in promoting myeloid differentiation in APL might be related to its ability to restore a normal subnuclear organization. Expand