Skip to search formSkip to main contentSkip to account menu

CDC34 gene

Known as: Cell Division Cycle 34 Homolog (S. cerevisiae) Gene, UBCH3, E2-CDC34 
This gene plays a role in protein ubiquitination.
National Institutes of Health

Related topics

Related topics

3 relations
Ubiquitin-Conjugating Enzyme E2 R1Ubiquitinated Protein DegradationUbiquitination

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate.
Highly Cited
2010
Highly Cited
2010
Mechanisms of mono- and poly-ubiquitination: Ubiquitination specificity depends on compatibility between the E2 catalytic core and amino acid residues proximal to the lysine
Ubiquitination involves the attachment of ubiquitin to lysine residues on substrate proteins or itself, which can result in… 
Highly Cited
2005
Highly Cited
2005
Mechanism of Lysine 48-Linked Ubiquitin-Chain Synthesis by the Cullin-RING Ubiquitin-Ligase Complex SCF-Cdc34
Highly Cited
2003
Highly Cited
2003
Release of Ubiquitin-Charged Cdc34-S∼Ub from the RING Domain Is Essential for Ubiquitination of the SCFCdc4-Bound Substrate Sic1
Highly Cited
1998
Highly Cited
1998
Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast.
In budding yeast, ubiquitination of the cyclin-dependent kinase (Cdk) inhibitor Sic1 is catalyzed by the E2 ubiquitin conjugating… 
Highly Cited
1998
Highly Cited
1998
Association of human CUL‐1 and ubiquitin‐conjugating enzyme CDC34 with the F‐box protein p45SKP2: evidence for evolutionary conservation in the subunit composition of the CDC34–SCF pathway
In normal and transformed cells, the F‐box protein p45SKP2 is required for S phase and forms stable complexes with p19SKP1 and… 
Highly Cited
1998
Highly Cited
1998
Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1.
Ubiquitin-mediated proteolysis controls the abundance of many cell cycle regulatory proteins. Recent work in Saccharomyces… 
Highly Cited
1997
Highly Cited
1997
SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities.
Traversal from G1 to S-phase in cycling cells of budding yeast is dependent on the destruction of the S-phase cyclin/CDK… 
Highly Cited
1993
Highly Cited
1993
Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast.
In a screen designed to isolate human cDNAs that complement a yeast G2 phase checkpoint mutation (mec1), we isolated a cDNA… 
Highly Cited
1992
Highly Cited
1992
A chimeric ubiquitin conjugating enzyme that combines the cell cycle properties of CDC34 (UBC3) and the DNA repair properties of RAD6 (UBC2): implications for the structure, function and evolution of…
The CDC34 (UBC3) protein from Saccharomyces cerevisiae has a 125 residue tail that contains a polyacidic region flanked on either… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)