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Mechanism of anchoring of OmpA protein to the cell wall peptidoglycan of the gram‐negative bacterial outer membrane
The outer membrane protein A (OmpA) plays important roles in anchoring of the outer membrane to the bacterial cell wall. The C‐terminal periplasmic domain of OmpA (OmpA‐like domain) associates withExpand
Structure of PP4397 reveals the molecular basis for different c-di-GMP binding modes by Pilz domain proteins.
Cyclic diguanylate (c-di-GMP) is a global regulator that modulates pathogen virulence and biofilm formation in bacteria. Although a bioinformatic study revealed that PilZ domain proteins are theExpand
Binding Surface Mapping of Intra- and Interdomain Interactions among hHR23B, Ubiquitin, and Polyubiquitin Binding Site 2 of S5a*
hHR23B is the human homologue of the yeast protein RAD23 and is known to participate in DNA repair by stabilizing xeroderma pigmentosum group C protein. However, hHR23B and RAD23 also have manyExpand
Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway
In eukaryotic cells, apoptosis and cell cycle arrest by the Ras → RASSF → MST pathway are controlled by the interaction of SARAH (for Salvador/Rassf/Hippo) domains in the C-terminal part of tumorExpand
Structure of the Cdt1 C‐terminal domain: Conservation of the winged helix fold in replication licensing factors
In eukaryotic replication licensing, Cdt1 plays a key role by recruiting the MCM2‐7 complex onto the origin of chromosome. The C‐terminal domain of mouse Cdt1 (mCdt1C), the most conserved region inExpand
Biophysical Characterization of the Interaction Domains and Mapping of the Contact Residues in the XPF-ERCC1 Complex*
XPF and ERCC1 exist as a heterodimer to be stable and active in cells and catalyze DNA cleavage on the 5′-side of a lesion during nucleotide excision repair. To characterize the specific interactionExpand
Stereospecific mechanism of DJ‐1 glyoxalases inferred from their hemithioacetal‐containing crystal structures
DJ‐1 family proteins have recently been characterized as novel glyoxalases, although their cofactor‐free catalytic mechanisms are not fully understood. Here, we obtained crystals of ArabidopsisExpand
The Human Cdc34 Carboxyl Terminus Contains a Non-covalent Ubiquitin Binding Activity That Contributes to SCF-dependent Ubiquitination*
Cdc34 is an E2 ubiquitin-conjugating enzyme that functions in conjunction with SCF (Skp1·Cullin 1·F-box) E3 ubiquitin ligase to catalyze covalent attachment of polyubiquitin chains to a targetExpand
Differential Ubiquitin Binding by the Acidic Loops of Ube2g1 and Ube2r1 Enzymes Distinguishes Their Lys-48-ubiquitylation Activities*
Background: The acidic loops of E2 enzymes are important for their Lys-48-ubiquitylation activity. Results: The presence of Tyr residues modulates the ubiquitin binding property of the acidic loop.Expand
NMR Application Probes a Novel and Ubiquitous Family of Enzymes That Alter Monosaccharide Configuration*
By exploiting nuclear magnetic resonance (NMR) techniques along with novel applications of saturation difference analysis, we deciphered the functions of the previously uncharacterized products ofExpand