Ubiquitinated Protein Degradation
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Basal protein turnover, which largely relies on the degradation of ubiquitinated substrates, is instrumental for maintenance of… Expand Basal autophagy plays an essential role as a protein quality control system. Although it has been demonstrated that the loss of… Expand The ubiquitin–proteasome system (UPS) and autophagy are two distinct and interacting proteolytic systems. They play critical… Expand In eukaryotic cells, proteasomes exist primarily as 26S holoenzymes, the most efficient configuration for ubiquitinated protein… Expand Background: Lafora disease involves impaired glycogen metabolism and protein degradation. Results: Impaired proteasomal… Expand Marinesco–Sjögren syndrome (MSS) features cerebellar ataxia, mental retardation, cataracts, and progressive vacuolar myopathy… Expand p62 is a multidomain protein that contains different kinds of protein-protein interaction domains, including an N-terminal PB1… Expand Post-translational modification of protein lysines was recently shown to be a common feature of eukaryotic organisms. The… Expand