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CD40 Ligand

Known as: TRAP ligand, T-Cell gp39 Antigen, T-cell antigen gp39 
A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces… 
National Institutes of Health

Related topics

Related topics

18 relations
CD40 AntigensCD40LG geneCD40LG wt AlleleIn Blood

Narrower (2)

CD40 Ligand, humanRecombinant CD40-Ligand

Papers overview

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Highly Cited
2010
Highly Cited
2010
CD4 T Cells Are Not Required for the Induction of Dengue Virus-Specific CD8 T Cell or Antibody Responses but Contribute to Protection after Vaccination
The contribution of T cells to the host response to dengue virus (DENV) infection is not well understood. We previously… 
Review
2004
Review
2004
B cells as therapeutic targets for rheumatic diseases
Purpose of reviewTrials treating human rheumatic diseases with biologic agents and drugs that selectively affect B cells will be… 
Highly Cited
2003
Highly Cited
2003
Stimulating PD-1–negative signals concurrent with blocking CD154 co-stimulation induces long-term islet allograft survival1
Background. A balanced network of positive and negative T-cell co-stimulatory signals is important in regulating T-cell… 
Highly Cited
2002
Highly Cited
2002
Cutting Edge: Precursor Frequency Affects the Helper Dependence of Cytotoxic T Cells1
Generation of CTL immunity often depends on the availability of CD4 T cell help. In this report, we show that CTL responses… 
Highly Cited
2001
Highly Cited
2001
Phase I clinical trial of a monoclonal antibody against CD40-ligand (IDEC-131) in patients with systemic lupus erythematosus.
OBJECTIVE To investigate the safety and pharmacology of a humanized monoclonal antibody against CD40-ligand (IDEC-131) in… 
Highly Cited
2000
Highly Cited
2000
The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo.
We used signal transducer and activator of transcription 4 (STAT4) and STAT6 gene knockout (-/-) mice as recipients of fully… 
Highly Cited
2000
Highly Cited
2000
Dendritic cells modified to express CD40 ligand elicit therapeutic immunity against preexisting murine tumors.
CD40 ligand (CD40L) is essential for the initiation of antigen-specific T-cell responses. This study is based on the hypothesis… 
Highly Cited
1999
Highly Cited
1999
Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance.
BACKGROUND Thymic irradiation (TI) or repeated administration of T cell-depleting monoclonal antibodies (TCD mAbs) is required in… 
Review
1996
Review
1996
Molecular, structural, and biological characteristics of the tumor necrosis factor ligand superfamily
  • H. Gruss
  • International journal of clinical & laboratory…
  • 1996
  • Corpus ID: 24424910
The tumor necrosis factor receptor superfamily at present consists of ten different transmembrane (type I) glycoproteins with… 
Highly Cited
1993
Highly Cited
1993
CD40 ligand is a T cell growth factor
CD40 ligand (CD40L) is a 33‐kDa type II membrane glycoprotein induced on T cells upon activation. CD40L has previously been shown… 
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