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The regulatory functions of Siglecs (sialic acid binding immunoglobulin-like lectins) in the immune system provide opportunities… Expand ABSTRACT West Nile virus (WNV) is a RNA virus of the family Flaviviridae and the leading cause of mosquito-borne encephalitis in… Expand CD22 (Siglec‐2) is a B‐cell membrane‐bound lectin that recognizes glycan ligands containing α2,6‐linked sialic acid (α2,6Sia) and… Expand CD22 (Siglec-2) is a key regulator of B cell signaling whose function is modulated by interaction with extracellular glycan… Expand The Siglec family of receptors mediates cell surface interactions through recognition of sialylated glycoconjugates. The crystal… Expand The common sialic acids of mammalian cells areN-acetylneuraminic acid (Neu5Ac) andN-glycolylneuraminic acid (Neu5Gc). Humans are… Expand Mice in which the Lyn, Cd22, or Shp-1 gene has been disrupted have hyperactive B cells and autoantibodies. We find that in the… Expand CD22 is a B lineage-restricted member of the Ig superfamily that serves as an adhesion receptor expressed by mature B lymphocytes… Expand Background. Cell adhesion molecules (CAM) may determine the patterns of growth and dissemination of lymphoproliferative disorders… Expand We have cloned a full-length cDNA for the B cell membrane protein CD22, which is referred to as B lymphocyte cell adhesion… Expand