Skip to search formSkip to main contentSkip to account menu

CD22 antigen

Known as: Sialic Acid Binding Ig like Lectin 2, CD22 Glycoprotein, Antigen, CD22 
A lectin and cell adhesion molecule found in B-LYMPHOCYTES. It interacts with SIALIC ACIDS and mediates signaling from B-CELL ANTIGEN RECEPTORS.
National Institutes of Health

Related topics

Related topics

14 relations

Broader (2)

CD AntigensCell Adhesion Molecules
CD22 Expressing Cell CountCD22 geneImmunoglobulin DomainsIn Blood

Narrower (1)

CD22 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Proximity labeling of cis-ligands of CD22/Siglec-2 reveals stepwise α2,6 sialic acid-dependent and -independent interactions.
2013
2013
C-4 modified sialosides enhance binding to Siglec-2 (CD22): towards potent Siglec inhibitors for immunoglycotherapy.
The regulatory functions of Siglecs (sialic acid binding immunoglobulin-like lectins) in the immune system provide opportunities… 
Highly Cited
2006
Highly Cited
2006
High-Affinity Ligand Probes of CD22 Overcome the Threshold Set by cis Ligands to Allow for Binding, Endocytosis, and Killing of B Cells1
CD22 (Siglec-2) is a key regulator of B cell signaling whose function is modulated by interaction with extracellular glycan… 
Highly Cited
2003
Highly Cited
2003
Structure-guided design of sialic acid-based Siglec inhibitors and crystallographic analysis in complex with sialoadhesin.
Highly Cited
2000
Highly Cited
2000
Loss of N-Glycolylneuraminic Acid in Human Evolution
The common sialic acids of mammalian cells areN-acetylneuraminic acid (Neu5Ac) andN-glycolylneuraminic acid (Neu5Gc). Humans are… 
Highly Cited
1998
Highly Cited
1998
Inhibition of the B Cell by CD22: A Requirement for Lyn
Mice in which the Lyn, Cd22, or Shp-1 gene has been disrupted have hyperactive B cells and autoantibodies. We find that in the… 
Highly Cited
1993
Highly Cited
1993
The same epitope on CD22 of B lymphocytes mediates the adhesion of erythrocytes, T and B lymphocytes, neutrophils, and monocytes.
CD22 is a B lineage-restricted member of the Ig superfamily that serves as an adhesion receptor expressed by mature B lymphocytes… 
1993
1993
Differential expression of cell adhesion molecules in b‐zone small lymphocytic lymphoma and other well‐differentiated lymphocytic disorders
Background. Cell adhesion molecules (CAM) may determine the patterns of growth and dissemination of lymphoproliferative disorders… 
Highly Cited
1991
Highly Cited
1991
cDNA cloning of the B cell membrane protein CD22: a mediator of B-B cell interactions
We have cloned a full-length cDNA for the B cell membrane protein CD22, which is referred to as B lymphocyte cell adhesion… 
1990
1990
Analysis of leukocyte surface antigens on ethanol-fixed paraffin-embedded tissue material.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)