CD22 gene

Despite high remission rates following CAR-T cell therapy in B-ALL, relapse due to loss of the targeted antigen is increasingly… Expand

In vitro antibody affinity maturation has generally been achieved by display of mouse or human antibodies on the surface of… Expand

CD22 is a negative regulator of B-cell receptor signaling, an activity mediated by recruitment of SH2 domain–containing… Expand

Abstract CD22, a member of the immunoglobulin superfamily, is a B-cell transmembrane glycoprotein that acts as an accessory… Expand

The development of B lymphocytes is a highly regulated process that depends in part on lineage-specific cell surface molecules… Expand

B cell activation following antigen receptor cross-linking can be augmented in vitro by ligation of cell surface CD22, which… Expand

CD22 is an immunoglobulin superfamily B lymphocyte-specific adhesion receptor and a member of the recently identified I-type… Expand

CD22 is a B lineage-restricted member of the Ig superfamily that serves as an adhesion receptor expressed by mature B lymphocytes… Expand

The antigen receptor on B lymphocytes is composed of membrane immunoglobulin sheathed by an α/β heterodimer. This structure is in… Expand

The human B lymphocyte-specific Ag, CD22, is a cell adhesion molecule expressed on the surface during a narrow window of B cell… Expand