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CD22 gene

Known as: CD22, SIALIC ACID-BINDING IMMUNOGLOBULIN-LIKE LECTIN 2, CD22 molecule 
This gene is involved in mediating the adhesion between B cells and is a molecular marker for B-cell precursor acute lymphocytic leukemia.
National Institutes of Health

Papers overview

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Highly Cited
2018
Highly Cited
2018
Despite high remission rates following CAR-T cell therapy in B-ALL, relapse due to loss of the targeted antigen is increasingly… Expand
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Highly Cited
2006
Highly Cited
2006
In vitro antibody affinity maturation has generally been achieved by display of mouse or human antibodies on the surface of… Expand
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Highly Cited
2005
Highly Cited
2005
CD22 is a negative regulator of B-cell receptor signaling, an activity mediated by recruitment of SH2 domain–containing… Expand
Highly Cited
1999
Highly Cited
1999
Abstract CD22, a member of the immunoglobulin superfamily, is a B-cell transmembrane glycoprotein that acts as an accessory… Expand
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Review
1997
Review
1997
The development of B lymphocytes is a highly regulated process that depends in part on lineage-specific cell surface molecules… Expand
Highly Cited
1996
Highly Cited
1996
B cell activation following antigen receptor cross-linking can be augmented in vitro by ligation of cell surface CD22, which… Expand
1996
1996
CD22 is an immunoglobulin superfamily B lymphocyte-specific adhesion receptor and a member of the recently identified I-type… Expand
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Highly Cited
1993
Highly Cited
1993
CD22 is a B lineage-restricted member of the Ig superfamily that serves as an adhesion receptor expressed by mature B lymphocytes… Expand
Highly Cited
1993
Highly Cited
1993
The antigen receptor on B lymphocytes is composed of membrane immunoglobulin sheathed by an α/β heterodimer. This structure is in… Expand
Highly Cited
1992
Highly Cited
1992
The human B lymphocyte-specific Ag, CD22, is a cell adhesion molecule expressed on the surface during a narrow window of B cell… Expand