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CD163 protein, human

Known as: Scavenger Receptor Cysteine-Rich Type 1 Protein M130, Macrophage-Associated Antigen, CD163 
Scavenger receptor cysteine-rich type 1 protein M130 (1156 aa, ~125 kDa) is encoded by the human CD163 gene. This protein plays a role in clearance… 
National Institutes of Health

Related topics

Related topics

14 relations

Broader (1)

CD163 antigen
CD163 geneCD163 wt AlleleIntracellular MembranesLigand Binding

Papers overview

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Highly Cited
2018
Highly Cited
2018
CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis
Intake of hemoglobin by the hemoglobin-haptoglobin receptor CD163 leads to a distinct alternative non–foam cell antiinflammatory… 
Highly Cited
2010
Highly Cited
2010
CXCL4 Downregulates the Atheroprotective Hemoglobin Receptor CD163 in Human Macrophages
Rationale: CXCL4 is a platelet-derived chemokine that promotes macrophage differentiation from monocytes. Deletion of the PF4… 
Highly Cited
2009
Highly Cited
2009
The Minor Envelope Glycoproteins GP2a and GP4 of Porcine Reproductive and Respiratory Syndrome Virus Interact with the Receptor CD163
ABSTRACT Porcine reproductive and respiratory syndrome virus (PRRSV) contains the major glycoprotein, GP5, as well as three other… 
Highly Cited
2007
Highly Cited
2007
A Previously Unrecognized Protein-Protein Interaction between TWEAK and CD163: Potential Biological Implications1
TWEAK (TNF-like weak inducer of apoptosis) is a TNF superfamily member implicated in several mechanisms. Although fibroblast… 
Highly Cited
2007
Highly Cited
2007
The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor alpha-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritis.
OBJECTIVE Macrophage activation syndrome is characterized by an overwhelming inflammatory reaction driven by excessive expansion… 
Highly Cited
2006
Highly Cited
2006
Constitutive Endocytosis of CD163 Mediates Hemoglobin-Heme Uptake and Determines the Noninflammatory and Protective Transcriptional Response of Macrophages to Hemoglobin
Heme toxicity contributes to the pathogenesis of chronic inflammatory diseases, atherosclerosis, and hemolysis associated… 
Highly Cited
2005
Highly Cited
2005
Expression of CD163 (Hemoglobin Scavenger Receptor) in Normal Tissues, Lymphomas, Carcinomas, and Sarcomas Is Largely Restricted to the Monocyte/Macrophage Lineage
CD163, a hemoglobin scavenger receptor, is expressed in monocytes and macrophages. We tested the expression of the CD163 protein… 
Highly Cited
2000
Highly Cited
2000
Human monocytes express CD163, which is upregulated by IL-10 and identical to p155.
CD163 is a glucocorticoid-inducible member of the scavenger receptor cysteine-rich family of proteins. Previous reports have… 
Highly Cited
1999
Highly Cited
1999
Regulation of CD163 on human macrophages: cross‐linking of CD163 induces signaling and activation
CD163 is a member of the group B scavenger receptor cysteine‐rich (SRCR) superfamily. This study describes aspects of the tissue… 
Highly Cited
1993
Highly Cited
1993
A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily
The antibodies Ki‐M8, Ber‐Mac3, GHI/61 and SM4 define a human macrophage‐associated antigen with a relative molecular mass of… 
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