Regulation of CD163 on human macrophages: cross‐linking of CD163 induces signaling and activation

@article{Heuvel1999RegulationOC,
  title={Regulation of CD163 on human macrophages: cross‐linking of CD163 induces signaling and activation},
  author={Michel M. Heuvel and Cornelis P. Tensen and Jaco H. As and Timo K. Van Den Berg and Donna M. Fluitsma and Christine D. Dijkstra and Ed A. Döpp and Annette Droste and Floris A. Gaalen and Clemens Prof. Dr. Sorg and Petra H{\"o}gger and Robert H. J. Beelen},
  journal={Journal of Leukocyte Biology},
  year={1999},
  volume={66}
}
CD163 is a member of the group B scavenger receptor cysteine‐rich (SRCR) superfamily. This study describes aspects of the tissue distribution, the regulation of expression, and signal transduction after cross‐linking of this receptor at the cell surface of macrophages. CD163 showed an exclusive expression on resident macrophages (e.g., red pulp macrophages, alveolar macrophages). The expression was inducible on monocyte‐derived macrophages by glucocorticoids but not by interleukin‐4 (IL‐4… 
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