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CCR2 wt Allele

Known as: CMKBR2, CCR2A, CC-CKR-2 
Human CCR2 wild-type allele is located in the vicinity of 3p21.31 and is approximately 7 kb in length. This allele, which encodes C-C chemokine… Expand
National Institutes of Health

Related topics

Related topics

15 relations
3p21.31C-C Chemokine Receptor Type 2ChemotaxisCytokine Receptor Activation
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Broader (1)

CCR2 gene

Papers overview

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Highly Cited
2010
Highly Cited
2010
Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b.
For adoptive T-cell therapy to be effective against solid tumors, tumor-specific T cells must be able to migrate to the tumor… Expand
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Highly Cited
2007
Highly Cited
2007
CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature.
Chemokines and chemokine receptors have been posited to have important roles in several common malignancies, including breast and… Expand
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Highly Cited
2006
Highly Cited
2006
Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers.
Keratinocytes and dermal endothelial cells, excluding leukocytes that infiltrate wounds, are the main source of soluble factors… Expand
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Highly Cited
2005
Highly Cited
2005
Evidence for negative binding cooperativity within CCR5-CCR2b heterodimers.
It is well established that most G protein-coupled receptors are able to form homo- and heterodimers, although the functional… Expand
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Highly Cited
2004
Highly Cited
2004
Cytoreductive surgery and intraperitoneal chemohyperthermia for peritoneal carcinomatosis arising from gastric cancer.
HYPOTHESIS The most common cause of palliative resection and recurrence in gastric cancer is peritoneal seeding. This study… Expand
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Highly Cited
1998
Highly Cited
1998
Monomeric monocyte chemoattractant protein-1 (MCP-1) binds and activates the MCP-1 receptor CCR2B.
To address the role of dimerization in the function of the monocyte chemoattractant protein-1, MCP-1, we mutated residues that… Expand
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Highly Cited
1998
Highly Cited
1998
The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor.
The chemokines are a growing family of low m.w., 70- to 80-residue proinflammatory cytokines that operate by interacting with G… Expand
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Highly Cited
1996
Highly Cited
1996
Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha.
Chemokines affect leukocyte chemotactic and activation activities through specific G protein-coupled receptors. In an effort to… Expand
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Highly Cited
1996
Highly Cited
1996
Molecular cloning and functional expression of a new human CC-chemokine receptor gene.
The cloning of several receptors activated by either CC or CXC chemokines and belonging to the G protein-coupled family of… Expand
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Highly Cited
1996
Highly Cited
1996
Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes
Several studies have shown that CC chemokines attract T lymphocytes, and that CD45RO+, memory phenotype cells are considered to… Expand
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