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Mechano-transduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer associated fibroblasts
Analysis of fibroblasts from different stages of breast cancer progression reveal that activation of the YAP transcription factor is a signature feature of CAFs, and actomyosin contractility and Src function are required for YAP activation by stiff matrices.
Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6
It is shown that collective invasion by cancer cells depends on decreasing actomyosin contractility at sites of cell–cell contact, and a molecular mechanism for this downregulation is provided.
CCR5 promoter polymorphisms, CCR5 59029A and CCR5 59353C, are under represented in HIV-1-infected long-term non-progressors
This study provides the first evidence for an association between CCR5 promoter polymorphisms and long-term asymptomatic HIV-1 infection, with individuals lacking the C CR5 59029A/ CCR 5 59353C homozygous genotype likely to progress more slowly towards AIDS and/or death.
The influence of extracellular matrix and prolactin on global gene expression profiles of primary bovine mammary epithelial cells in vitro.
An in vitro bovine mammosphere model was characterized for use in lactational biology studies using a functional genomics approach and a number of novel Prl responsive genes were identified, including ECM components and genes involved in differentiation and apoptosis.
A functional genomics approach to evaluate candidate genes located in a QTL interval for milk production traits on BTA6.
- P. Sheehy, L. Riley, H. Raadsma, P. Williamson, P. Wynn
- Biology, MedicineAnimal genetics
- 1 August 2009
Analysis of candidate gene expression and the effects of gene knockdown on expression of beta- and kappa-casein mRNA in a small interfering RNA transfected bovine in vitro mammosphere model suggest that the gene product of SPP1 (also known as osteopontin) has a significant role in the modulation of milk protein gene expression.
Marked differences in the structures and protein associations of lymphocyte and monocyte CD4: Resolution of a novel CD4 isoform
It is hypothesized that, when CD4 inter‐β‐sheet disulfides in the D1 and D4 Ig folds are disrupted, there is an unravelling of the oxidized form to an extended 59 kDa unfolded state, which may be a transition‐state, structural‐intermediate in the formation of disulfide‐linked homodimers.
Lactation and Neonatal Nutrition: Defining and Refining the Critical Questions
- M. Neville, S. M. Anderson, P. Williamson
- MedicineJournal of Mammary Gland Biology and Neoplasia
- 1 July 2012
A roadmap for multidisciplinary research into all aspects of human lactation, milk and its role in infant nutrition for the next decade and beyond is presented.
Analysis of the expression of immunoglobulins throughout lactation suggests two periods of immune transfer in the tammar wallaby (Macropus eugenii).
HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line
- S. Schibeci, Alison O. Clegg, R. Biti, K. Sagawa, G. Stewart, P. Williamson
- Biology, MedicineAIDS
- 18 August 2000
Enhanced IL-2 production in stimulated T cells expressing HIV-Nef is associated with increased activation of PI3K-dependent signalling pathways, which support a model in which Nef affects HIV disease progression by distorting T cell responses.
Comparative Analysis of Genome Diversity in Bullmastiff Dogs
While current levels of Bullmastiff heterozygosity, inbreeding and homozygosity are not unusual, a relatively small effective population size indicates that a breeding strategy to reduce the inbreeding rate may be beneficial.