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C-C Chemokine Receptor Type 2

Known as: CCR2, CC-CKR-2, MCP-1-R 
C-C chemokine receptor type 2 (374 aa, ~42 kDa) is encoded by the human CCR2 gene. This protein plays a role in both cytokine binding and receptor… Expand
National Institutes of Health

Related topics

Related topics

23 relations
CCR2 geneCCR2 wt AlleleChemokine Receptor GeneChemotaxis
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Resolving postoperative neuroinflammation and cognitive decline
Cognitive decline accompanies acute illness and surgery, especially in the elderly. Surgery engages the innate immune system that… Expand
Highly Cited
2009
Highly Cited
2009
Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis
In addition to liver‐resident Kupffer cells, infiltrating immune cells have recently been linked to the development of liver… Expand
Highly Cited
2008
Highly Cited
2008
Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes
OBJECTIVE—To establish the mechanism of the phenotypic switch of adipose tissue macrophages (ATMs) from an alternatively… Expand
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Highly Cited
2008
Highly Cited
2008
Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii.
The enteric pathogen Toxoplasma gondii is controlled by a vigorous innate T helper 1 (Th1) cell response in the murine model. We… Expand
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Highly Cited
2007
Highly Cited
2007
Obesity induces a phenotypic switch in adipose tissue macrophage polarization.
Adipose tissue macrophages (ATMs) infiltrate adipose tissue during obesity and contribute to insulin resistance. We hypothesized… Expand
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Highly Cited
2007
Highly Cited
2007
Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease
Microglia are the principal immune cells of the brain. In Alzheimer disease, these brain mononuclear phagocytes are recruited… Expand
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Highly Cited
2006
Highly Cited
2006
CCR2 modulates inflammatory and metabolic effects of high-fat feeding.
The C-C motif chemokine receptor-2 (CCR2) regulates monocyte and macrophage recruitment and is necessary for macrophage-dependent… Expand
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Highly Cited
2003
Highly Cited
2003
An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice
The study and treatment of age-related macular degeneration (AMD), a leading cause of blindness, has been hampered by a lack of… Expand
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Highly Cited
2000
Highly Cited
2000
Resistance to Experimental Autoimmune Encephalomyelitis in Mice Lacking the Cc Chemokine Receptor (Ccr2)
Monocyte recruitment to the central nervous system (CNS) is a necessary step in the development of pathologic inflammatory… Expand
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Highly Cited
1997
Highly Cited
1997
Defects in Macrophage Recruitment and Host Defense in Mice Lacking the CCR2 Chemokine Receptor
Chemokines are a structurally related family of cytokines that are important for leukocyte trafficking. The C-C chemokine… Expand
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