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CA9 wt Allele

Known as: Carbonic Anhydrase IX wt Allele, G250, CA9 
Human CA9 wild-type allele is located in the vicinity of 9p13.3 and is approximately 7 kb in length. This allele, which encodes carbonic anhydrase 9… 
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4
BackgroundThe cellular response of malignant tumors to hypoxia is diverse. Several important endogenous metabolic markers are… 
Highly Cited
2009
Highly Cited
2009
The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy
Basal-like tumours account for 15% of invasive breast carcinomas and are associated with a poorer prognosis and resistance to… 
Highly Cited
2008
Highly Cited
2008
Tumor-associated Carbonic Anhydrase 9 Spatially Coordinates Intracellular pH in Three-dimensional Multicellular Growths*
CA9 is a membrane-tethered, carbonic anhydrase (CA) enzyme, expressed mainly at the external surface of cells, that catalyzes… 
Highly Cited
2006
Highly Cited
2006
Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients…
PURPOSE Randomized controlled trials have generally shown a benefit from accelerated radiotherapy in head and neck squamous cell… 
Highly Cited
2006
Highly Cited
2006
Ambulatory Arterial Stiffness Index Derived From 24-Hour Ambulatory Blood Pressure Monitoring
We hypothesized that 1 minus the slope of diastolic on systolic pressure during 24-hour ambulatory monitoring (ambulatory… 
Highly Cited
2002
Highly Cited
2002
Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival.
PURPOSE Tumor hypoxia is known to be associated with resistance to chemotherapy, radiotherapy, and poorer survival. Recently, it… 
Highly Cited
2001
Highly Cited
2001
Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer.
Carbonic anhydrase-9 (CA9), a transmembrane enzyme with an extracellular active site, is involved in the reversible metabolism of… 
Highly Cited
2001
Highly Cited
2001
Hypoxia-regulated carbonic anhydrase-9 (CA9) relates to poor vascularization and resistance of squamous cell head and neck cancer to chemoradiotherapy.
PURPOSE Carbonic anhydrases are proteins involved in the catalytic hydration of carbon dioxide to carbonic acid. Recent studies… 
Highly Cited
2000
Highly Cited
2000
Molecular cloning and immunogenicity of renal cell carcinoma‐associated antigen G250
The molecular cloning of the cDNA and gene encoding the renal cell carcinoma (RCC)‐associated protein G250 is described. This… 
Highly Cited
1997
Highly Cited
1997
Identification of the MN/CA9 protein as a reliable diagnostic biomarker of clear cell carcinoma of the kidney.
The MN/CA9 protein is a tumor-associated antigen that has been shown to have diagnostic utility in identifying cervical dysplasia… 
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